PMID- 14670133
OWN - NLM
STAT- MEDLINE
DCOM- 20040615
LR  - 20190513
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 27
IP  - 8
DP  - 2003 Nov-Dec
TI  - Concentrations and ratios of amphetamine, methamphetamine, MDA, MDMA, and MDEA 
      enantiomers determined in plasma samples from clinical toxicology and driving 
      under the influence of drugs cases by GC-NICI-MS.
PG  - 552-9
AB  - Enantiomers of amphetamine (AM), methamphetamine (MA), 
      3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), 
      and 3,4-methylenedioxyethylamphetamine (MDEA) exhibit different pharmacological 
      properties. This may be important for the interpretation of analytical results. 
      Plasma samples were analyzed using validated negative ion chemical ionization gas 
      chromatography-mass spectrometry procedures. The results for clinical toxicology 
      cases, divided into screening (SCR) and intoxication (ITX) cases, and those of 
      driving under the influence of drugs (DUID) cases were compared. The 
      concentrations of all enantiomers, except R-(-)-MDA and R-(-)- and S-(+)-MA, in 
      the SCR samples were lower than in ITX and DUID samples. Differences between 
      concentrations in ITX and DUID samples were only significant for both enantiomers 
      of AM (DUID higher). These findings suggested impairment in drugged drivers. 
      Different enantiomer ratios (R vs. S) were found for AM between DUID and SCR 
      samples, for MDMA between ITX and SCR samples, and for MDA between DUID and ITX 
      and DUID and SCR samples. Higher MDMA enantiomer ratios in SCR compared to ITX 
      samples are in accordance with a previously described increase of those ratios 
      over time, possibly allowing differentiation of recent from nonrecent ingestion. 
      Pharmacokinetic analysis of a MDMA poisoning yielded elimination half-lives of 
      6.0 h for R-(-)-MDMA and 4.1 h for S-(+)-MDMA. The enantiomer ratios rose 
      exponentially over time.
FAU - Peters, F T
AU  - Peters FT
AD  - Department of Experimental and Clinical Toxicology, Institute of Experimental and 
      Clinical Pharmacology and Toxicology, University of Saarland, D-66421 Homburg 
      (Saar), Germany.
FAU - Samyn, N
AU  - Samyn N
FAU - Wahl, M
AU  - Wahl M
FAU - Kraemer, T
AU  - Kraemer T
FAU - De Boeck, G
AU  - De Boeck G
FAU - Maurer, H H
AU  - Maurer HH
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/blood/chemistry
MH  - Adult
MH  - Amphetamine/blood/chemistry
MH  - Amphetamines/blood/chemistry
MH  - Automobile Driving
MH  - Central Nervous System Stimulants/*blood/chemistry
MH  - Forensic Medicine
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Male
MH  - Methamphetamine/blood/chemistry
MH  - N-Methyl-3,4-methylenedioxyamphetamine/blood/chemistry
MH  - Stereoisomerism
MH  - Substance Abuse Detection/methods
EDAT- 2003/12/13 05:00
MHDA- 2004/06/16 05:00
CRDT- 2003/12/13 05:00
PHST- 2003/12/13 05:00 [pubmed]
PHST- 2004/06/16 05:00 [medline]
PHST- 2003/12/13 05:00 [entrez]
AID - 10.1093/jat/27.8.552 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2003 Nov-Dec;27(8):552-9. doi: 10.1093/jat/27.8.552.