PMID- 1467031
OWN - NLM
STAT- MEDLINE
DCOM- 19930128
LR  - 20190503
IS  - 0007-0769 (Print)
IS  - 0007-0769 (Linking)
VI  - 68
IP  - 5
DP  - 1992 Nov
TI  - Ventilation in chronic heart failure: effects of physical training.
PG  - 473-7
AB  - OBJECTIVE: To assess the effects of exercise training on ventilatory function in 
      chronic heart failure. DESIGN: Observer blinded random allocation crossover 
      training and detraining trial. SETTING: Assessment in hospital based clinical 
      laboratory; training home based. PATIENTS: 22 patients with chronic heart failure 
      (New York Heart Association (NYHA) class II or III) recruited from a tertiary 
      referral centre. All finished the study. INTERVENTION: Bicycle ergometer exercise 
      for 20 minutes a day, five days a week for eight weeks at 70%-80% of maximum 
      heart rate. MAIN OUTCOME MEASURES: Exercise capacity on graded incremental 
      exercise test, minute ventilation, oxygen consumption and carbon dioxide output. 
      RESULTS: Peak work load increased from 96 W to 112 W and peak oxygen consumption 
      from 14.1 ml/kg/min to 15.4 ml/kg/min (p < 0.01). At submaximal workloads carbon 
      dioxide excretion (VCO2) and minute ventilation (Vi) decreased significantly (p < 
      0.05) though oxygen consumption was unchanged. The relation between Vi and carbon 
      dioxide excretion changed: the slope of the Vi to VCO2 plot decreased from 38.6 
      to 35.3, indicating an improvement in overall ventilary efficiency. The 
      instantaneous carbon dioxide ventilatory equivalent (Vi/VCO2) decreased at 
      submaximal workloads, and reached a lower minimum value after training, 
      indicating that optimum ventilatory performance improved. The exercise capacity 
      of patients was related to the optimum ventilatory performance. It is suggested 
      that this may in part be mediated through changes in skeletal muscles. 
      CONCLUSION: Exercise training reduces the ventilatory abnormalities in chronic 
      heart failure; thus some of these changes may be due to physical deconditioning.
FAU - Davey, P
AU  - Davey P
AD  - Department of Cardiology, John Radcliffe Hospital, Oxford.
FAU - Meyer, T
AU  - Meyer T
FAU - Coats, A
AU  - Coats A
FAU - Adamopoulos, S
AU  - Adamopoulos S
FAU - Casadei, B
AU  - Casadei B
FAU - Conway, J
AU  - Conway J
FAU - Sleight, P
AU  - Sleight P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br Heart J
JT  - British heart journal
JID - 0370634
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Aged
MH  - Carbon Dioxide/metabolism
MH  - Chronic Disease
MH  - Evaluation Studies as Topic
MH  - Heart Failure/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/physiology
MH  - *Physical Education and Training
MH  - Random Allocation
MH  - Respiration/*physiology
MH  - Single-Blind Method
PMC - PMC1025190
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
PMCR- 1992/11/01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PHST- 1992/11/01 00:00 [pmc-release]
AID - 10.1136/hrt.68.11.473 [doi]
PST - ppublish
SO  - Br Heart J. 1992 Nov;68(5):473-7. doi: 10.1136/hrt.68.11.473.