PMID- 14671251
OWN - NLM
STAT- MEDLINE
DCOM- 20040126
LR  - 20161122
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 35
IP  - 1
DP  - 2004 Jan
TI  - Decreased levels of plasma vitamin C and increased concentrations of inflammatory 
      and oxidative stress markers after stroke.
PG  - 163-8
AB  - BACKGROUND AND PURPOSE: Inflammatory response is a critical component of the 
      complex pathophysiological response to stroke. Vitamin C has been shown to have 
      important roles in cell performance and vascular function. In this study, we 
      compared the nutritional status and levels of inflammatory markers between stroke 
      cases and controls and assessed which antioxidant was associated with levels of 
      inflammatory markers and oxidative stress among cases and controls. METHODS: We 
      evaluated the nutritional status and measured plasma levels of vitamins C and E, 
      uric acid, serum levels of C-reactive protein (CRP), the cytokines tumor necrosis 
      factor-alpha and interleukin-1beta, intercellular adhesion molecule-1 (ICAM-1) 
      and chemokine monocyte chemoattractant protein-1 (MCP-1), prostaglandins PGE2 and 
      PGI2, and 8-isoprostanes (8-epiPGF2alpha) for 15 patients with ischemic stroke 
      within 2 to 5 days after stroke onset and for 24 control subjects. RESULTS: 
      Stroke patients had significantly lower plasma levels of vitamin C than did 
      controls. Among stroke patients, CRP was significantly elevated, as were the 
      ICAM-1, MCP-1, and 8-epiPGF2alpha, but the prostaglandins PGE2 and PGI2 were 
      significantly reduced. Interestingly, vitamin C concentration was significantly 
      inversely correlated with the levels of CRP and 8-epiPGF2alpha among stroke 
      patients, and 8-epiPGF2alpha was significantly associated with the levels of CRP. 
      Uric acid was also elevated among stroke patients. CONCLUSIONS: Lower vitamin C 
      concentration, higher serum levels of inflammatory (CRP, ICAM-1, MCP-1) and 
      oxidative stress (8-epiPGF2alpha) markers, and lower PGI2 and PGE2 concentrations 
      among stroke patients indicate the presence of an inflammatory response 
      associated with stroke.
FAU - Sanchez-Moreno, Concepcion
AU  - Sanchez-Moreno C
AD  - Nutrition and Neurocognition Laboratory, Jean Mayer USDA-Human Nutrition Research 
      Center on Aging, Boston, Mass 02111, USA.
FAU - Dashe, John F
AU  - Dashe JF
FAU - Scott, Tammy
AU  - Scott T
FAU - Thaler, David
AU  - Thaler D
FAU - Folstein, Marshal F
AU  - Folstein MF
FAU - Martin, Antonio
AU  - Martin A
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20031211
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Prostaglandins)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 1406-18-4 (Vitamin E)
RN  - 268B43MJ25 (Uric Acid)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - B7IN85G1HY (Dinoprost)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Aged
MH  - Antioxidants/analysis
MH  - Ascorbic Acid/*blood
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/complications
MH  - C-Reactive Protein/analysis
MH  - Chemokine CCL2/blood
MH  - Cytokines/blood
MH  - Diet
MH  - Dinoprost/*analogs & derivatives/blood
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Nutritional Status
MH  - *Oxidative Stress
MH  - Prostaglandins/blood
MH  - Reference Values
MH  - Stroke/*blood/complications
MH  - Time Factors
MH  - Uric Acid/blood
MH  - Vitamin E/blood
EDAT- 2003/12/13 05:00
MHDA- 2004/01/27 05:00
CRDT- 2003/12/13 05:00
PHST- 2003/12/13 05:00 [pubmed]
PHST- 2004/01/27 05:00 [medline]
PHST- 2003/12/13 05:00 [entrez]
AID - 01.STR.0000105391.62306.2E [pii]
AID - 10.1161/01.STR.0000105391.62306.2E [doi]
PST - ppublish
SO  - Stroke. 2004 Jan;35(1):163-8. doi: 10.1161/01.STR.0000105391.62306.2E. Epub 2003 
      Dec 11.