PMID- 14672962
OWN - NLM
STAT- MEDLINE
DCOM- 20041013
LR  - 20220330
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 96
IP  - 4
DP  - 2004 Apr
TI  - Influence of carbohydrate ingestion on immune changes after 2 h of intensive 
      resistance training.
PG  - 1292-8
AB  - Thirty strength-trained subjects were randomized to carbohydrate (CHO) or placebo 
      (Pla) groups and lifted weights for 2 h (10 exercises, 4 sets each, 10 
      repetitions, with 2- to 3-min rest intervals). Subjects received 10 ml x kg(-1) x 
      h(-1) CHO (6%) or Pla beverages during the weight training bout. Blood, saliva, 
      and vastus lateralis muscle biopsy samples were collected before and after 
      exercise. Blood cell counts were determined, and plasma was analyzed for IL-6, 
      IL-10, IL-1 receptor antagonist (IL-1ra), IL-8, and cortisol. Muscle was analyzed 
      for glycogen content and relative gene expression of 13 cytokines (IL-1alpha, 
      IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p35, IL-12p40, IL-15, 
      IFN-gamma, TNF-alpha) by use of real-time quantitative RT-PCR. Significant but 
      modest increases were measured for plasma IL-6, IL-10, IL-1ra, and IL-8, but the 
      pattern of increase did not differ between CHO and Pla groups. The rate of 
      decrease in muscle glycogen content did not differ between CHO and Pla (P = 
      0.463). Muscle cytokine mRNA was detected preexercise for IL-1beta, IL-6, IL-15, 
      IL-8, and TNF-alpha, and of these, IL-1beta, IL-6, IL-8, and TNF-alpha were 
      significantly increased after the 2-h weight training bout. The increase in mRNA 
      (fold difference from preexercise) did not differ between CHO and Pla groups. In 
      summary, CHO vs. Pla ingestion did not alter modest increases measured for plasma 
      IL-6, IL-10, IL-1ra, and IL-8, and muscle gene expression for IL-1beta, IL-6, 
      IL-8, and TNF-alpha in strength-trained subjects lifting weights intensively for 
      2 h.
FAU - Nieman, D C
AU  - Nieman DC
AD  - Department of Health, Appalachian State University, Boone, NC 28608, USA. 
      niemandc@appstate.edu
FAU - Davis, J M
AU  - Davis JM
FAU - Brown, V A
AU  - Brown VA
FAU - Henson, D A
AU  - Henson DA
FAU - Dumke, C L
AU  - Dumke CL
FAU - Utter, A C
AU  - Utter AC
FAU - Vinci, D M
AU  - Vinci DM
FAU - Downs, M F
AU  - Downs MF
FAU - Smith, J C
AU  - Smith JC
FAU - Carson, J
AU  - Carson J
FAU - Brown, A
AU  - Brown A
FAU - McAnulty, S R
AU  - McAnulty SR
FAU - McAnulty, L S
AU  - McAnulty LS
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20031212
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Carbohydrates)
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
RN  - 9005-79-2 (Glycogen)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Blood Cell Count
MH  - Carbohydrates/*administration & dosage
MH  - Cytokines/blood/genetics/metabolism
MH  - Gene Expression
MH  - Glycogen/antagonists & inhibitors
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Immune System/*drug effects/*physiology
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - *Physical Endurance
MH  - RNA, Messenger/metabolism
MH  - Time Factors
MH  - Weight Lifting/*physiology
EDAT- 2003/12/16 05:00
MHDA- 2004/10/14 09:00
CRDT- 2003/12/16 05:00
PHST- 2003/12/16 05:00 [pubmed]
PHST- 2004/10/14 09:00 [medline]
PHST- 2003/12/16 05:00 [entrez]
AID - 01064.2003 [pii]
AID - 10.1152/japplphysiol.01064.2003 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2004 Apr;96(4):1292-8. doi: 
      10.1152/japplphysiol.01064.2003. Epub 2003 Dec 12.