PMID- 14673216
OWN - NLM
STAT- MEDLINE
DCOM- 20040209
LR  - 20220309
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 48
IP  - 4
DP  - 2003
TI  - Association study of a brain-derived neurotrophic-factor genetic polymorphism and 
      mood disorders, age of onset and suicidal behavior.
PG  - 186-9
AB  - Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin growth 
      factor family, has been implicated in both mood disorders and suicidal behavior. 
      This study has examined the association between the BDNF gene Val66Met 
      polymorphism and mood disorders, age of onset and suicidal behavior in a Chinese 
      sample population. The genotype and allele frequencies for the BDNF gene Val66Met 
      polymorphism did not differ comparing depression groups (total, bipolar disorder 
      or major depression) and control subjects. Furthermore, it was not demonstrated 
      that this BDNF polymorphism was associated with age of onset or suicidal history 
      in our mood disorder patients. Based on these results, it seems reasonable to 
      suggest that this polymorphism is unlikely to play a major role in the genetic 
      susceptibility to mood disorders. Given the fact that the positive association 
      between BDNF gene Val66Met polymorphism and bipolar disorder has only been 
      demonstrated for a Caucasian population but not for a Japanese analog or our 
      Chinese sample, it appears likely that this association is ethnicity dependent.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Hong, Chen-Jee
AU  - Hong CJ
AD  - Department of Psychiatry, Veterans General Hospital-Taipei, Taipei, Taiwan, ROC.
FAU - Huo, Sheue-Jane
AU  - Huo SJ
FAU - Yen, Feng-Chang
AU  - Yen FC
FAU - Tung, Chun-Liang
AU  - Tung CL
FAU - Pan, Guo-Mei
AU  - Pan GM
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - *Age of Onset
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Mood Disorders/*genetics
MH  - *Polymorphism, Genetic
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Sequence Analysis/methods
MH  - *Suicide
MH  - Valine/genetics
EDAT- 2003/12/16 05:00
MHDA- 2004/02/11 05:00
CRDT- 2003/12/16 05:00
PHST- 2003/12/16 05:00 [pubmed]
PHST- 2004/02/11 05:00 [medline]
PHST- 2003/12/16 05:00 [entrez]
AID - 74636 [pii]
AID - 10.1159/000074636 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2003;48(4):186-9. doi: 10.1159/000074636.