PMID- 14673549
OWN - NLM
STAT- MEDLINE
DCOM- 20040330
LR  - 20181113
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 55
IP  - 10
DP  - 2004 Jan
TI  - Nucleotide sequencing analysis of the swine 433-kb genomic segment located 
      between the non-classical and classical SLA class I gene clusters.
PG  - 695-705
AB  - Genome analysis of the swine leukocyte antigen ( SLA) region is needed to obtain 
      information on the MHC genomic sequence similarities and differences between the 
      swine and human, given the possible use of swine organs for xenotransplantation. 
      Here, the genomic sequences of a 433-kb segment located between the non-classical 
      and classical SLA class I gene clusters were determined and analyzed for gene 
      organization and contents of repetitive sequences. The genomic organization and 
      diversity of this swine non-class I gene region was compared with the orthologous 
      region of the human leukocyte antigen ( HLA) complex. The length of the fully 
      sequenced SLA genomic segment was 433 kb compared with 595 kb in the 
      corresponding HLA class I region. This 162-kb difference in size between the 
      swine and human genomic segments can be explained by indel activity, and the 
      greater variety and density of repetitive sequences within the human MHC. 
      Twenty-one swine genes with strong sequence similarity to the corresponding human 
      genes were identified, with the gene order from the centromere to telomere of HCR 
      - SPR1 - SEEK1 - CDSN - STG - DPCR1 - KIAA1885 - TFIIH - DDR - IER3 - FLOT1 - 
      TUBB - KIAA0170 - NRM - KIAA1949 - DDX16 - FLJ13158 - MRPS18B - FB19 - ABCFI - 
      CAT56. The human SEEK1 and DPCR1 genes are pseudogenes in swine. We conclude that 
      the swine non-class I gene region that we have sequenced is highly conserved and 
      therefore homologous to the corresponding region located between the HLA-C and 
      HLA-E genes in the human.
FAU - Shigenari, Atsuko
AU  - Shigenari A
AD  - Department of Molecular Life Science, Tokai University School of Medicine, 
      Bohseidai, Isehara, 259-1193, Kanagawa, Japan.
FAU - Ando, Asako
AU  - Ando A
FAU - Renard, Christine
AU  - Renard C
FAU - Chardon, Patrick
AU  - Chardon P
FAU - Shiina, Takashi
AU  - Shiina T
FAU - Kulski, Jerzy K
AU  - Kulski JK
FAU - Yasue, Hiroshi
AU  - Yasue H
FAU - Inoko, Hidetoshi
AU  - Inoko H
LA  - eng
SI  - GENBANK/AB113354
SI  - GENBANK/AB113355
SI  - GENBANK/AB113356
SI  - GENBANK/AB113357
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20031212
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (swine leukocyte antigen)
SB  - IM
MH  - Animals
MH  - Contig Mapping
MH  - Gene Duplication
MH  - HLA Antigens/genetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Antigens Class II
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics
MH  - Molecular Sequence Data
MH  - Pseudogenes
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Nucleic Acid
MH  - Species Specificity
MH  - Swine/*genetics
EDAT- 2003/12/16 05:00
MHDA- 2004/03/31 05:00
CRDT- 2003/12/16 05:00
PHST- 2003/08/08 00:00 [received]
PHST- 2003/11/06 00:00 [revised]
PHST- 2003/12/16 05:00 [pubmed]
PHST- 2004/03/31 05:00 [medline]
PHST- 2003/12/16 05:00 [entrez]
AID - 10.1007/s00251-003-0627-0 [doi]
PST - ppublish
SO  - Immunogenetics. 2004 Jan;55(10):695-705. doi: 10.1007/s00251-003-0627-0. Epub 
      2003 Dec 12.