PMID- 14673579
OWN - NLM
STAT- MEDLINE
DCOM- 20040224
LR  - 20220408
IS  - 0340-5354 (Print)
IS  - 0340-5354 (Linking)
VI  - 250
IP  - 12
DP  - 2003 Dec
TI  - Cognitive impairment: a key feature of congestive heart failure in the elderly.
PG  - 1456-63
AB  - Congestive heart failure (CHF) has been proposed as a possible cause of cognitive 
      dysfunction but only a few studies have directly assessed cognitive performance 
      in CHF. The aim of the present study was to compare the cognitive patterns of 
      patients with CHF and patients having cardiovascular diseases uncomplicated by 
      CHF (no-CHF group). In a multicenter observational case-control study, we studied 
      149 hospitalized elderly CHF patients in the New York Heart Association (NYHA) 
      class II (CHFm, m: moderate), 159 CHF patients in NYHA class III-IV (CHFs, s: 
      severe), and 207 no-CHF patients. Patients underwent a multidimensional 
      assessment and neuropsychological tests for the following cognitive domains: 
      attention, visual-spatial intelligence, verbal attainment, verbal and 
      visuo-spatial memory. Neuropsychological performances of groups were compared by 
      multivariate analysis. Correlates of an abnormal performance on at least three 
      neuropsychological tests were assessed by logistic regression analysis. CHFs 
      performed worse than no-CHF patients on 4 of the 7 neuropsychological measures, 
      the largest difference being in tests of attention and verbal learning (p < 
      0.001). Prevalence of abnormal performance on at least 3 tests was 57.9 % in 
      CHFs, 43% in CHFm and 34.3 % in no-CHF groups (chi square = 17.3, p < 0.0001). 
      The following qualified as independent correlates of the outcome at logistic 
      regression analysis: CHFs group membership (Odds Ratio-OR = 2.56, 95% Confidence 
      Interval-CI = 1.49-4.40), depression (OR = 2.37, 95% CI = 1.54-3.66), 
      hypertension (OR = 1.88, 95% CI = 1.18-2.99). Our results demonstrate that 
      cognitive impairment is common among CHF patients and seems to be causally 
      related to CHF severity, depression and hypertension. The cognitive dysfunction 
      also characterizes a relevant fraction of patients with cardiovascular diseases 
      uncomplicated by CHF.
FAU - Trojano, Luigi
AU  - Trojano L
AD  - Dept. of Psychology, 2nd University of Naples, Caserta, Italy. 
      luigi.trojano@unina2.it
FAU - Antonelli Incalzi, Raffaele
AU  - Antonelli Incalzi R
FAU - Acanfora, Domenico
AU  - Acanfora D
FAU - Picone, Costantino
AU  - Picone C
FAU - Mecocci, Patrizia
AU  - Mecocci P
FAU - Rengo, Franco
AU  - Rengo F
CN  - Congestive Heart Failure Italian Study Investigators
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - Case-Control Studies
MH  - Cognition Disorders/*etiology
MH  - Female
MH  - Heart Failure/*complications
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Risk Factors
EDAT- 2003/12/16 05:00
MHDA- 2004/02/26 05:00
CRDT- 2003/12/16 05:00
PHST- 2003/03/11 00:00 [received]
PHST- 2003/07/21 00:00 [revised]
PHST- 2003/07/25 00:00 [accepted]
PHST- 2003/12/16 05:00 [pubmed]
PHST- 2004/02/26 05:00 [medline]
PHST- 2003/12/16 05:00 [entrez]
AID - 10.1007/s00415-003-0249-3 [doi]
PST - ppublish
SO  - J Neurol. 2003 Dec;250(12):1456-63. doi: 10.1007/s00415-003-0249-3.