PMID- 14674929
OWN - NLM
STAT- MEDLINE
DCOM- 20040511
LR  - 20190823
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 1
DP  - 2004 Jan
TI  - Monitoring the allergic inflammation.
PG  - 26-32
AB  - Individual symptoms of allergy such as asthma, dermatitis, rhinitis have many 
      different underlying mechanisms. The detailed characterization of the 
      inflammatory mechanisms underlying symptom development in the individual patient 
      is important in order to optimally control treatment. Measurement of eosinophil 
      cationic protein (ECP) in sputum or blood and eosinophil protein X/eosinophil 
      derived neurotoxin (EPX/EDN) in urine may be used to read the involvement of the 
      eosinophil granulocyte in the process. An important information as eosinophil 
      dominated processes seem to be particularly sensitive to corticosteroid 
      treatment. The possibilities to measure the involvement of other inflammatory 
      cells exist today, but are only used to a small extent. The dream would be that 
      every patient with an inflammatory disease is characterized with respect to the 
      profile of involving cells and mediators. Such information would provide us with 
      a unique understanding of the underlying mechanisms of the development of disease 
      symptoms and the possibilities of treating these.
FAU - Venge, P
AU  - Venge P
AD  - Department of Medical Sciences, Clinical Chemistry and Asthma and Allergy 
      Research Centre, Uppsala University, Uppsala, Sweden.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Blood Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 0 (Inflammation Mediators)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Asthma/immunology/physiopathology
MH  - Blood Proteins/analysis
MH  - Cytokines/analysis
MH  - Dermatitis, Atopic/immunology/physiopathology
MH  - Eosinophil Granule Proteins
MH  - Eosinophils/*immunology/physiology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*immunology/*physiopathology
MH  - Inflammation/*immunology/physiopathology
MH  - Inflammation Mediators/analysis/*metabolism
MH  - Male
MH  - Monitoring, Physiologic/methods
MH  - Neutrophils/immunology/metabolism
MH  - Prognosis
MH  - Rhinitis, Allergic, Perennial/immunology/physiopathology
MH  - Ribonucleases/analysis
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
RF  - 80
EDAT- 2003/12/17 05:00
MHDA- 2004/05/12 05:00
CRDT- 2003/12/17 05:00
PHST- 2003/12/17 05:00 [pubmed]
PHST- 2004/05/12 05:00 [medline]
PHST- 2003/12/17 05:00 [entrez]
AID - 386 [pii]
AID - 10.1046/j.1398-9995.2003.00386.x [doi]
PST - ppublish
SO  - Allergy. 2004 Jan;59(1):26-32. doi: 10.1046/j.1398-9995.2003.00386.x.