PMID- 14674935
OWN - NLM
STAT- MEDLINE
DCOM- 20040511
LR  - 20190823
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 1
DP  - 2004 Jan
TI  - Lack of association of HLA class I genes and TNF alpha-308 polymorphism in 
      toluene diisocyanate-induced asthma.
PG  - 61-4
AB  - BACKGROUND: Toluene diisocyanate (TDI)-induced asthma is a common cause of 
      occupational asthma and it affects 5-15% of the exposed population suggesting an 
      underlying genetic susceptibility. METHODS: To investigate the role of genetic 
      factors in the development of TDI-induced asthma, we analyzed the distribution of 
      human leukocyte antigen (HLA) class I genes and of tumor necrosis factor 
      (TNF)-alpha A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 
      asymptomatic exposed subjects. RESULTS: Neither the distribution of HLA class I 
      antigens nor the distribution of TNF-alpha A-308G polymorphism was different 
      between patients with TDI-induced asthma and asymptomatic exposed subjects. 
      CONCLUSIONS: These results suggest that HLA class I antigens and TNF-alpha A-308G 
      are not associated with susceptibility or resistance to the development of 
      TDI-induced asthma.
FAU - Beghe, B
AU  - Beghe B
AD  - Section of Respiratory Diseases, Department of Clinical and Experimental 
      Medicine,University of Padua, Padua, Italy.
FAU - Padoan, M
AU  - Padoan M
FAU - Moss, C T
AU  - Moss CT
FAU - Barton, S J
AU  - Barton SJ
FAU - Holloway, J W
AU  - Holloway JW
FAU - Holgate, S T
AU  - Holgate ST
FAU - Howell, W M
AU  - Howell WM
FAU - Mapp, C E
AU  - Mapp CE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 17X7AFZ1GH (Toluene 2,4-Diisocyanate)
SB  - IM
MH  - Adult
MH  - Asthma/chemically induced/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/chemically induced/genetics
MH  - *Polymorphism, Genetic
MH  - Probability
MH  - Prognosis
MH  - Reference Values
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Toluene 2,4-Diisocyanate/*adverse effects
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2003/12/17 05:00
MHDA- 2004/05/12 05:00
CRDT- 2003/12/17 05:00
PHST- 2003/12/17 05:00 [pubmed]
PHST- 2004/05/12 05:00 [medline]
PHST- 2003/12/17 05:00 [entrez]
AID - 352 [pii]
AID - 10.1046/j.1398-9995.2003.00352.x [doi]
PST - ppublish
SO  - Allergy. 2004 Jan;59(1):61-4. doi: 10.1046/j.1398-9995.2003.00352.x.