PMID- 14675473
OWN - NLM
STAT- MEDLINE
DCOM- 20040423
LR  - 20191210
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 14
IP  - 6
DP  - 2003 Dec
TI  - Non-specific bronchial hyper-responsiveness in children with allergic rhinitis: 
      relationship with the atopic status.
PG  - 458-63
AB  - An increased prevalence of bronchial hyper-responsiveness (BHR) has been 
      demonstrated in children from a general population, and in non-asthmatic adults 
      with allergic rhinitis. Thus, also children with allergic rhinitis are expected 
      to be at higher risk of BHR. We evaluated the prevalence of BHR in a sample of 
      non-asthmatic children with allergic rhinitis by means of the methacholine (Mch) 
      bronchial challenge, and by monitorizing the airway patency using the daily peak 
      expiratory flow variability (PEFv). Fifty-one children (ranged 6-15 years of age) 
      with allergic rhinitis, ascertained by skin prick test to inhalant allergens, 
      underwent a 14-day peak expiratory flow monitoring, and a Mch bronchial 
      provocation challenge. Thirty healthy children matched for age, and sex served as 
      control group. Thirty-one children in the rhinitis group (61%), and six (20%) in 
      the control group were Mch+ (Mch provocative dose causing a 20% fall of forced 
      expiratory volume in 1 s respect to baseline <2250 microg, equivalent to 11.50 
      micromol). In rhinitic children the PEFv did not significantly differ between 
      Mch+ and Mch- subjects, but the total serum immunoglobulin E (IgE) were higher 
      among Mch+. The persistent form of rhinitis was significantly associated to Mch 
      positivity. Non-asthmatic children with allergic rhinitis displayed a high 
      prevalence of BHR. The BHR was significantly associated with persistent rhinitis 
      and with higher total IgE levels. Nevertheless, the spontaneous changes in airway 
      patency, as expressed by PEFv, were within normal limits both in Mch+ and Mch- 
      children.
FAU - Cuttitta, Giuseppina
AU  - Cuttitta G
AD  - Istituto di Biomedicina e Immunologia Molecolare 'Alberto Monroy' del C.N.R., 
      Palermo, Italy. cuttitta@ifr.pa.cnr.it
FAU - Cibella, Fabio
AU  - Cibella F
FAU - La Grutta, Stefania
AU  - La Grutta S
FAU - Hopps, Maria R
AU  - Hopps MR
FAU - Bucchieri, Salvatore
AU  - Bucchieri S
FAU - Passalacqua, Giovanni
AU  - Passalacqua G
FAU - Bonsignore, Giovanni
AU  - Bonsignore G
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Airway Resistance/physiology
MH  - Biomarkers/blood
MH  - Bronchial Hyperreactivity/*physiopathology
MH  - Bronchial Provocation Tests
MH  - Child
MH  - Child Welfare
MH  - Cross-Sectional Studies
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - Hypersensitivity, Immediate/physiopathology
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Peak Expiratory Flow Rate/physiology
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Respiratory Function Tests
MH  - Rhinitis, Allergic, Perennial/*physiopathology
MH  - Statistics as Topic
MH  - Vital Capacity/physiology
EDAT- 2003/12/17 05:00
MHDA- 2004/04/24 05:00
CRDT- 2003/12/17 05:00
PHST- 2003/12/17 05:00 [pubmed]
PHST- 2004/04/24 05:00 [medline]
PHST- 2003/12/17 05:00 [entrez]
AID - 067 [pii]
AID - 10.1046/j.0905-6157.2003.00067.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2003 Dec;14(6):458-63. doi: 
      10.1046/j.0905-6157.2003.00067.x.