PMID- 14675476
OWN - NLM
STAT- MEDLINE
DCOM- 20040423
LR  - 20191210
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 14
IP  - 6
DP  - 2003 Dec
TI  - Total and allergen-specific IgE levels in serum reflect blood eosinophilia and 
      fractional exhaled nitric oxide concentrations but not pulmonary functions in 
      allergic asthmatic children sensitized to house dust mites.
PG  - 475-81
AB  - Although elevated levels of serum immunoglobulin E (IgE) are considered the 
      hallmark of atopic diseases, their clinical value in evaluating subjects with 
      allergic disorders is under debate. To evaluate possible relationships between 
      serum IgE levels and a variety of clinical parameters, 83 mild asthmatic children 
      [10.98-year-old (2.95)], sensitized to house dust mites (HDM) Dermatophagoides 
      pteronyssinus (Dp) or D. farinae (Df), were enrolled. As compared with normal 
      control reference values detected in our laboratory, children with allergic 
      asthma had higher blood eosinophil counts (expressed both as percentage and as 
      absolute number) and higher fractional exhaled nitric oxide (FeNO) levels but 
      similar values in pulmonary function parameters. In the allergic asthmatic 
      population, serum levels of total, Dp-specific or Df-specific IgE correlated 
      positively with eosinophil counts (Rho > or = 0.30, p < 0.01, each correlation) 
      and FeNO levels (Rho > or = 0.33, p < 0.01, each correlation) but not with 
      pulmonary function parameters (p > 0.1, each correlation). Finally, significant 
      correlations, although moderate, were found in the allergic asthmatic population 
      between eosinophil counts and FeNO levels (Rho > or = 0.42, p < 0.001, each 
      correlation). Thus, in atopic children sensitized to HDM with mild intermittent 
      asthma, IgE levels in blood appear to reflect systemic (blood eosinophils) and 
      organ-specific (FeNO) markers of allergic inflammation but not pulmonary volumes 
      or the degree of airflow limitation.
FAU - Sacco, Oliviero
AU  - Sacco O
AD  - Pulmonary Unit, G. Gaslini Institute, Genoa, Italy.
FAU - Sale, Rosa
AU  - Sale R
FAU - Silvestri, Michela
AU  - Silvestri M
FAU - Serpero, Laura
AU  - Serpero L
FAU - Sabatini, Federica
AU  - Sabatini F
FAU - Raynal, Maria E
AU  - Raynal ME
FAU - Biraghi, Maurizio
AU  - Biraghi M
FAU - Rossi, Giovanni A
AU  - Rossi GA
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*blood/*immunology
MH  - Animals
MH  - Antibody Specificity/*immunology
MH  - Asthma/*blood/*immunology
MH  - Biomarkers/blood
MH  - Child
MH  - Child Welfare
MH  - Eosinophilia/*blood/*immunology
MH  - Exhalation/*immunology
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - *Immunization
MH  - Immunoglobulin E/*blood/*immunology
MH  - Italy/epidemiology
MH  - Lung/*metabolism/*physiopathology
MH  - Male
MH  - Nitric Oxide/*metabolism
MH  - Peak Expiratory Flow Rate/physiology
MH  - Pyroglyphidae/*immunology
MH  - Radioallergosorbent Test
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - Vital Capacity/physiology
EDAT- 2003/12/17 05:00
MHDA- 2004/04/24 05:00
CRDT- 2003/12/17 05:00
PHST- 2003/12/17 05:00 [pubmed]
PHST- 2004/04/24 05:00 [medline]
PHST- 2003/12/17 05:00 [entrez]
AID - 092 [pii]
AID - 10.1046/j.0905-6157.2003.00092.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2003 Dec;14(6):475-81. doi: 
      10.1046/j.0905-6157.2003.00092.x.