PMID- 14675601
OWN - NLM
STAT- MEDLINE
DCOM- 20040308
LR  - 20190724
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 217
IP  - 1
DP  - 2004 Jan 15
TI  - Natural course of voiding function in patients with human T-cell lymphotrophic 
      virus type 1-associated myelopathy.
PG  - 3-6
AB  - OBJECTIVES: Patients with human T-cell lymphotropic virus type I 
      (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) frequently 
      experience voiding dysfunction. In patients with HAM/TSP, the major symptoms are 
      gait disturbance and voiding dysfunction. However, the detailed natural course of 
      voiding function and the management of their urination has not previously been 
      investigated. We examined the correlation between voiding function and clinical 
      features and evaluated the management of urination, in the patients with HAM/TSP. 
      PATIENTS AND METHODS: The voiding function of 47 patients (7 males, 40 females, 
      aged 29-89 years, mean: 60.9 years) with HAM/TSP was analyzed retrospectively. 
      All HAM/TSP patients are positive for HTLV-1. Patients were referred to a 
      neurologist for analysis of bladder function. In the present study, we analyzed 
      their clinical details, age at disease onset, voiding function and alterations in 
      the management of their urination. Furthermore, we investigated the relationship 
      between urological management and the clinical features of HAM/TSP. RESULTS: Of 
      the 47 patients, 20 (42.5%) were able to void with or without drug therapy. 
      Thirty-four (72.3%) experienced clean intermittent self-catheterization (CIC), 
      with 25 of these 34 continuing CIC, 7 changing to voiding and 2 changing to 
      management with the Foley catheter. No relationship was noted between disruption 
      of voiding function and either age or gender. However, significant inverse 
      correlation was observed between the age at disease onset and the time to CIC 
      (r=-0.77, P=0.00001). CONCLUSIONS: These data suggest that the younger a patients 
      is at HAM/TSP onset, the longer voiding function will be maintained.
FAU - Mori, Ken-ichi
AU  - Mori K
AD  - Department of Urology, Nagasaki University Graduate School of Medicine, Nagasaki 
      City, Nagasaki 852-8501, Japan. moriyuuta@hotmail.com
FAU - Noguchi, Mitsuru
AU  - Noguchi M
FAU - Matsuo, Manabu
AU  - Matsuo M
FAU - Nomata, Koichiro
AU  - Nomata K
FAU - Nakamura, Tatsufumi
AU  - Nakamura T
FAU - Kanetake, Hiroshi
AU  - Kanetake H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Human T-lymphotropic virus 1/pathogenicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/epidemiology/*physiopathology
MH  - Retrospective Studies
MH  - Time Factors
MH  - Urinary Catheterization/methods
MH  - Urination Disorders/*etiology/virology
EDAT- 2003/12/17 05:00
MHDA- 2004/03/09 05:00
CRDT- 2003/12/17 05:00
PHST- 2003/12/17 05:00 [pubmed]
PHST- 2004/03/09 05:00 [medline]
PHST- 2003/12/17 05:00 [entrez]
AID - S0022510X03002429 [pii]
AID - 10.1016/j.jns.2003.08.004 [doi]
PST - ppublish
SO  - J Neurol Sci. 2004 Jan 15;217(1):3-6. doi: 10.1016/j.jns.2003.08.004.