PMID- 14676438
OWN - NLM
STAT- MEDLINE
DCOM- 20040805
LR  - 20220311
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 18
IP  - 6
DP  - 2003 Dec
TI  - Lung matrix metalloproteinase-9 correlates with cigarette smoking and obstruction 
      of airflow.
PG  - 821-7
AB  - Cigarette smoking is the most important risk factor for obstruction of airflow in 
      chronic obstructive pulmonary disease (COPD). Matrix metalloproteinases (MMPs) or 
      an imbalance between MMPs and their inhibitors, the tissue inhibitors of MMP 
      (TIMPs), is considered to play a role in the pathogenesis of COPD. We 
      investigated whether the MMPs expression or the imbalance between MMPs and TIMP-1 
      is associated with the amount of cigarette smoking and the FEV1 value, in the 
      lung parenchyma of 26 subjects (6 non-smokers and 20 cigarette smokers). First, 
      we performed zymographic analysis to identify the profile of the MMPs, which 
      revealed gelatinolytic bands mainly equivalent to MMP-9 in the smokers. We then 
      measured, using enzyme immunoassay, the concentrations of MMP-9 and its 
      inhibitor, TIMP-1. Correlation analysis revealed that both the MMP-9 
      concentrations and the molar ratios of MMP-9 to TIMP-1 (MMP-9/TIMP-1) were 
      correlated with the amount of cigarette smoking. Furthermore, MMP-9 
      concentrations were inversely correlated with FEV1. In conclusion, this study 
      shows that MMP-9 expression in human lung parenchyma is associated with cigarette 
      smoking and also with the obstruction of airflow, suggesting that MMP-9 may play 
      a role in the pathogenesis of the cigarette smoke-induced obstruction of airflow 
      known as the characteristic of COPD.
FAU - Kang, Min Jong
AU  - Kang MJ
AD  - Department of Internal Medicine, Hallym University Sacred Heart Hospital, College 
      of Medicine, Hallym University, Anyang, Korea.
FAU - Oh, Yeon-Mok
AU  - Oh YM
FAU - Lee, Jae Cheol
AU  - Lee JC
FAU - Kim, Dong Gyu
AU  - Kim DG
FAU - Park, Myung Jae
AU  - Park MJ
FAU - Lee, Myung Goo
AU  - Lee MG
FAU - Hyun, In Gyu
AU  - Hyun IG
FAU - Han, Sung Koo
AU  - Han SK
FAU - Shim, Young-Soo
AU  - Shim YS
FAU - Jung, Ki-Suck
AU  - Jung KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Lung/*enzymology
MH  - Male
MH  - Matrix Metalloproteinase 9/*metabolism
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*etiology
MH  - *Pulmonary Ventilation
MH  - *Smoking
MH  - Statistics as Topic
MH  - Tissue Inhibitor of Metalloproteinase-1/metabolism
PMC - PMC3055149
EDAT- 2003/12/17 05:00
MHDA- 2004/08/06 05:00
PMCR- 2003/12/01
CRDT- 2003/12/17 05:00
PHST- 2003/12/17 05:00 [pubmed]
PHST- 2004/08/06 05:00 [medline]
PHST- 2003/12/17 05:00 [entrez]
PHST- 2003/12/01 00:00 [pmc-release]
AID - 200312821 [pii]
AID - 10.3346/jkms.2003.18.6.821 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2003 Dec;18(6):821-7. doi: 10.3346/jkms.2003.18.6.821.