PMID- 14678832
OWN - NLM
STAT- MEDLINE
DCOM- 20041025
LR  - 20191108
IS  - 1567-133X (Print)
IS  - 1567-133X (Linking)
VI  - 4
IP  - 1
DP  - 2004 Jan
TI  - A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts with the 
      muscle-specific kinase (MuSK).
PG  - 77-84
AB  - Formation of the postsynaptic membrane at the skeletal neuromuscular junction 
      (NMJ) requires activation of the muscle-specific receptor tyrosine kinase (MuSK). 
      Few intracellular mediators or modulators of MuSK actions are known. E3 ubiquitin 
      ligases may serve this role, because activities of several receptor tyrosine 
      kinases, G-protein-coupled receptors and channels are modulated by 
      ubiquitination. Here, we report identification of a putative Ariadne-like 
      ubiquitin ligase (PAUL) that binds to the cytoplasmic domain of MuSK. PAUL is 
      expressed in numerous tissues of developing and adult mice, and is present at 
      NMJs in muscle fibers but is not confined to them.
FAU - Bromann, Paul A
AU  - Bromann PA
AD  - Department of Anatomy and Neurobiology, Washington University Medical School, 660 
      South Euclid, St Louis, MO 63110, USA.
FAU - Weiner, Joshua A
AU  - Weiner JA
FAU - Apel, Elizabeth D
AU  - Apel ED
FAU - Lewis, Renate M
AU  - Lewis RM
FAU - Sanes, Joshua R
AU  - Sanes JR
LA  - eng
SI  - GENBANK/AY283085
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Gene Expr Patterns
JT  - Gene expression patterns : GEP
JID - 101167473
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.3.2.27 (Rnf31 protein, mouse)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Brain/embryology/metabolism
MH  - Cell Line
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Developmental
MH  - Gene Expression Regulation, Enzymologic
MH  - Humans
MH  - In Situ Hybridization
MH  - Kidney/embryology/metabolism
MH  - Liver/embryology/metabolism
MH  - Lung/cytology/embryology/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscle, Skeletal/cytology/embryology/metabolism
MH  - Myocardium/cytology/metabolism
MH  - Phylogeny
MH  - Precipitin Tests
MH  - Protein Binding
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptor Protein-Tyrosine Kinases/genetics/*metabolism
MH  - Receptors, Cholinergic/genetics/*metabolism
MH  - Two-Hybrid System Techniques
MH  - Ubiquitin-Protein Ligases/*genetics/metabolism
EDAT- 2003/12/18 05:00
MHDA- 2004/10/27 09:00
CRDT- 2003/12/18 05:00
PHST- 2003/12/18 05:00 [pubmed]
PHST- 2004/10/27 09:00 [medline]
PHST- 2003/12/18 05:00 [entrez]
AID - S1567133X03001467 [pii]
AID - 10.1016/s1567-133x(03)00146-7 [doi]
PST - ppublish
SO  - Gene Expr Patterns. 2004 Jan;4(1):77-84. doi: 10.1016/s1567-133x(03)00146-7.