PMID- 14678903
OWN - NLM
STAT- MEDLINE
DCOM- 20040422
LR  - 20061115
IS  - 1000-2588 (Print)
IS  - 1000-2588 (Linking)
VI  - 23
IP  - 12
DP  - 2003 Dec
TI  - [Association of autoantibody and cytokines with latent autoimmune diabetes in 
      adults].
PG  - 1323-5
AB  - OBJECTIVE: To assess the clinical value of detecting glutamic acid decarboxylase 
      antibody (GADA), islet cell antibody (ICA) and cytokines in the diagnosis of 
      latent autoimmune diabetes in adults (LADA), and define the characteristics of 
      the two different types of LADA. METHODS: A total of 500 patients with an initial 
      diagnosis of type 2 diabetes mellitus (T2DM) were tested for GADA, ICA and 
      cytokines by enzyme-linked immunosorbent assay. RESULTS: In type 2 diabetic 
      patients approximately 11% were positive for GADA, who had similar symptoms as 
      hypertension, hyperlipidemia and other diabetic complications to justify the 
      diagnosis of LADA-2 subtype. Another 9.6% of the total patients were 
      ICA-positive, and when compared with T2DM, these patients had similar clinical 
      findings typical of type 1 diabetes such as younger age of onset, impaired beta 
      cell function and dependence on insulin treatment. Therefore they had more 
      resemblance to insulin-dependent diabetes and can be diagnosed as having LADA-1 
      subtype. It was also found that cytokines positively acted on GADA and ICA, 
      showing positive correlation between them. CONCLUSION: LADA has LADA-1 and LADA-2 
      subtypes, and GADA, ICA and cytokines test have important clinical significance 
      for diagnosis of LADA.
FAU - He, Feng-Ping
AU  - He FP
AD  - Clinical Laboratory Center, First Affiliated Hospital, Guangxi Medical 
      University, Nanning 530021, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Di Yi Jun Yi Da Xue Xue Bao
JT  - Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
JID - 9426110
RN  - 0 (Autoantibodies)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (islet cell antibody)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoantibodies/*blood
MH  - Diabetes Mellitus, Type 1/complications/*immunology
MH  - Female
MH  - Glutamate Decarboxylase/*immunology
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 2003/12/18 05:00
MHDA- 2004/04/23 05:00
CRDT- 2003/12/18 05:00
PHST- 2003/12/18 05:00 [pubmed]
PHST- 2004/04/23 05:00 [medline]
PHST- 2003/12/18 05:00 [entrez]
PST - ppublish
SO  - Di Yi Jun Yi Da Xue Xue Bao. 2003 Dec;23(12):1323-5.