PMID- 14680758
OWN - NLM
STAT- MEDLINE
DCOM- 20040528
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 46
IP  - 2
DP  - 2004 Feb
TI  - Decreased social behaviour following 3,4-methylenedioxymethamphetamine (MDMA) is 
      accompanied by changes in 5-HT2A receptor responsivity.
PG  - 202-10
AB  - This study examined the involvement of the 5-HT(2A) receptor in the long-term 
      anxiogenic effect of a brief exposure of young rats to 
      3,4-methylenedioxymethamphetamine (MDMA) using the social interaction and 
      elevated plus-maze paradigms. Wistar rats (post-natal day (PND) 28) received 
      either MDMA (5 mg/kg i.p.) or saline (1 ml/kg i.p.) hourly for 4 h on 2 
      consecutive days. Locomotor activity was measured for 60 min after the first 
      injection and core body temperature was recorded at regular intervals over 4 h. 
      On PND 84, without further drug administration, social interaction was assessed 
      between treatment-matched rat pairs derived from separate litters. On PND 86, 
      rats received either the 5-HT(2A/2C) receptor agonist, 
      1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI, 1 mg/kg i.p.) or saline and 
      locomotor activity, wet-dog shakes and back muscle contractions were monitored. 
      The change in elevated plus-maze behaviour was assessed following the same 
      injection on PND 87. Acutely, MDMA produced a significant hyperlocomotion and 
      hyperthermia (p<0.01). Following 55 days of abstinence, social interaction was 
      reduced by 27% in MDMA pre-treated rats compared with that in controls (p<0.01). 
      On the elevated plus-maze, pre-treatment with MDMA prevented the anxiogenic 
      effect of DOI. On PND 92, hippocampal, frontal cortical and striatal 
      5-hydroxytryptamine (5-HT) was significantly reduced in MDMA pre-treated rats by 
      between 16% and 22%, without any accompanying change in [(3)H]paroxetine binding 
      in cortical homogenates. In conclusion, exposure of young rats to repeated MDMA 
      caused serotonin depletion and induced 'anxiety-like' behaviour in the social 
      interaction test accompanied by a long-lasting reduction in specific 5-HT(2A) 
      receptor mediated behaviour.
FAU - Bull, Eleanor J
AU  - Bull EJ
AD  - Institute of Neuroscience, School of Biomedical Sciences, Queen's Medical Centre, 
      University of Nottingham, Nottingham NG7 2UH, UK. mbxejb@nottingham.ac.uk
FAU - Hutson, Peter H
AU  - Hutson PH
FAU - Fone, Kevin C F
AU  - Fone KC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Amphetamines)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Serotonin 5-HT2 Receptor Agonists)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - OOM10GW9UE (4-iodo-2,5-dimethoxyphenylisopropylamine)
SB  - IM
MH  - Amphetamines/pharmacology
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Male
MH  - Motor Activity/*drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Protein Binding/drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Serotonin, 5-HT2A/*metabolism
MH  - Serotonin 5-HT2 Receptor Agonists
MH  - *Social Behavior
EDAT- 2003/12/19 05:00
MHDA- 2004/05/29 05:00
CRDT- 2003/12/19 05:00
PHST- 2003/12/19 05:00 [pubmed]
PHST- 2004/05/29 05:00 [medline]
PHST- 2003/12/19 05:00 [entrez]
AID - S0028390803003447 [pii]
AID - 10.1016/j.neuropharm.2003.08.004 [doi]
PST - ppublish
SO  - Neuropharmacology. 2004 Feb;46(2):202-10. doi: 10.1016/j.neuropharm.2003.08.004.