PMID- 14680926
OWN - NLM
STAT- MEDLINE
DCOM- 20040115
LR  - 20081121
IS  - 0968-4328 (Print)
IS  - 0968-4328 (Linking)
VI  - 34
IP  - 8
DP  - 2003
TI  - A structural study of the retinal photoreceptor, plexiform and ganglion cell 
      layers following exposure to UV-B and UV-C radiation in the albino rat.
PG  - 395-404
AB  - Over the last two decades, ultraviolet radiation levels (UV), reaching the 
      Earth's surface, have been increasing at a rate of 1.5% per each 1% loss of the 
      ozone layer. Moreover, artificial UV-sources have also proliferated and 
      contributed to the rising UV-stress that many organisms have to face. To assess 
      how the vertebrate retina responds to an exposure of short wavelength UV, we 
      focused our attention on the rat retina, observing photoreceptor (containing 
      outer and inner segments of rods and cones), inner plexiform, and ganglion cell 
      layers by light and transmission electron microscopy using conventional and 
      cytochemical techniques. We analyzed how cells of the layers in question 
      responded to a 30 min exposure to UV-C and UV-B radiation with doses of 7200 and 
      590 J/cm(2), respectively. The results show that there are significant changes in 
      the nuclei and cytoplasmic organelles of the exposed retinae when compared with 
      those of the unexposed controls. The changes include an increase in 
      heterochromatin, distension of rough endoplasmic reticulum, mitochondrial 
      disruptions, and increases in the number of myelin bodies. The recorded 
      morphological changes, especially those of the ganglion cells, are suggestive of 
      apoptotic processes and show that the exposure of vertebrate retina to 
      wavelengths ranging from 254 to 312 nm can produce alterations that are likely to 
      impact negatively on the retina's proper functioning.
FAU - de Oliveira Miguel, Nadia Campos
AU  - de Oliveira Miguel NC
AD  - Departamento de Histologia e Embriologia, Centro de Ciencias da Saude (CCS), 
      Instituto de Ciencias Biomedicas (ICB), Universidade Federal do Rio de Janeiro, 
      Ilha do Fundao, 21941-590 Rio de Janeiro, RJ, Brazil.
FAU - Meyer-Rochow, Victor Benno
AU  - Meyer-Rochow VB
FAU - Allodi, Silvana
AU  - Allodi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Micron
JT  - Micron (Oxford, England : 1993)
JID - 9312850
SB  - IM
MH  - Animals
MH  - Histocytochemistry
MH  - Male
MH  - Microscopy, Electron
MH  - Photoreceptor Cells/radiation effects/ultrastructure
MH  - Rats
MH  - Rats, Wistar
MH  - Retina/*radiation effects/*ultrastructure
MH  - Retinal Ganglion Cells/radiation effects/ultrastructure
MH  - Ultraviolet Rays/*adverse effects
EDAT- 2003/12/19 05:00
MHDA- 2004/01/16 05:00
CRDT- 2003/12/19 05:00
PHST- 2003/01/18 00:00 [received]
PHST- 2003/06/03 00:00 [revised]
PHST- 2003/06/12 00:00 [accepted]
PHST- 2003/12/19 05:00 [pubmed]
PHST- 2004/01/16 05:00 [medline]
PHST- 2003/12/19 05:00 [entrez]
AID - S0968432803000817 [pii]
AID - 10.1016/S0968-4328(03)00081-7 [doi]
PST - ppublish
SO  - Micron. 2003;34(8):395-404. doi: 10.1016/S0968-4328(03)00081-7.