PMID- 14681760
OWN - NLM
STAT- MEDLINE
DCOM- 20040415
LR  - 20080116
IS  - 0174-304X (Print)
IS  - 0174-304X (Linking)
VI  - 34
IP  - 6
DP  - 2003 Dec
TI  - Subacute sclerosing panencephalitis in two brothers.
PG  - 326-9
AB  - We report the occurrence of subacute sclerosing panencephalitis (SSPE) in two 
      brothers two years after measles infection. The diagnosis was confirmed by 
      compatible data from medical history, occurrence of autochthonic measles virus 
      (MV) IgG production in the central nervous system (CNS), and pathognomonic EEG 
      changes. Pathogenetically, SSPE is caused by a genome mutation of intracellularly 
      persisting MV, causing viral nucleocapsides to accumulate in the brain cells. A 
      specific predisposing immune defect is not known. The occurrence of two cases in 
      one family is suggestive of a genetic predisposing factor.
FAU - Vieker, S
AU  - Vieker S
AD  - Kinderklinik Gilead, Bielefeld, Germany. Heinzel@Kinderklinik.gilead.de
FAU - Schmitt, J J
AU  - Schmitt JJ
FAU - Behrens, C
AU  - Behrens C
FAU - Weissbrich, B
AU  - Weissbrich B
FAU - Hartmann, H
AU  - Hartmann H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Neuropediatrics
JT  - Neuropediatrics
JID - 8101187
SB  - IM
MH  - Child
MH  - Humans
MH  - Male
MH  - *Siblings
MH  - Subacute Sclerosing Panencephalitis/*diagnosis
EDAT- 2003/12/19 05:00
MHDA- 2004/04/16 05:00
CRDT- 2003/12/19 05:00
PHST- 2003/12/19 05:00 [pubmed]
PHST- 2004/04/16 05:00 [medline]
PHST- 2003/12/19 05:00 [entrez]
AID - 10.1055/s-2003-44672 [doi]
PST - ppublish
SO  - Neuropediatrics. 2003 Dec;34(6):326-9. doi: 10.1055/s-2003-44672.