PMID- 14681916
OWN - NLM
STAT- MEDLINE
DCOM- 20040728
LR  - 20220408
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 124B
IP  - 1
DP  - 2004 Jan 1
TI  - Association between brain-derived neurotrophic factor 196 G/A polymorphism and 
      personality traits in healthy subjects.
PG  - 61-3
AB  - Several lines of evidence suggest that a certain type of personality or 
      temperament is at risk for developing neuropsychiatric diseases, and that 
      brain-derived neurotrophic factor (BDNF) might be involved in pathophysiology of 
      neuropsychiatric diseases such as mood disorders. Considering the role of BDNF 
      and personality traits in the neuropsychiatric diseases, it is of interest to 
      examine the association between BDNF gene polymorphism and personality test 
      scores. In this study, we examined the association between 196 G/A the 
      polymorphism in the coding region of the BDNF gene and personality traits scores 
      (temperament and character inventory (TCI) and NEO personality inventory 
      (NEO-PI)) in Japanese healthy subjects. We found that female, but not male, 
      subjects with BDNF genotype A/A have high scores in reward dependence on TCI and 
      high scores in extraversion on NEO-PI as compared with other genotypes (G/A or 
      G/G), suggesting an association between reward dependence (or extraversion) 
      personality traits and BDNF genotype in female subjects. Our findings suggest 
      that BDNF 196 A/G polymorphism might be associated with personality traits in 
      female, but not male, healthy subjects.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Itoh, Kanako
AU  - Itoh K
AD  - Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
FAU - Kumakiri, Chikara
AU  - Kumakiri C
FAU - Shimizu, Eiji
AU  - Shimizu E
FAU - Iyo, Masaomi
AU  - Iyo M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Personality
MH  - *Polymorphism, Single Nucleotide
MH  - Surveys and Questionnaires
EDAT- 2003/12/19 05:00
MHDA- 2004/07/29 05:00
CRDT- 2003/12/19 05:00
PHST- 2003/12/19 05:00 [pubmed]
PHST- 2004/07/29 05:00 [medline]
PHST- 2003/12/19 05:00 [entrez]
AID - 10.1002/ajmg.b.20078 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2004 Jan 1;124B(1):61-3. doi: 
      10.1002/ajmg.b.20078.