PMID- 14681930
OWN - NLM
STAT- MEDLINE
DCOM- 20040326
LR  - 20071114
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 468
IP  - 3
DP  - 2004 Jan 12
TI  - Anatomical evidence for transsynaptic influences of estrogen on brain-derived 
      neurotrophic factor expression.
PG  - 347-60
AB  - Several studies have demonstrated that estrogen modulates brain-derived 
      neurotrophic factor (BDNF) mRNA and protein within the adult hippocampus and 
      cortex. However, mechanisms underlying this regulation are unknown. Although an 
      estrogen response element (ERE)-like sequence has been identified within the BDNF 
      gene, such a classical mechanism of estrogen-induced transcriptional activation 
      requires the colocalized expression of estrogen receptors within cells that 
      produce BDNF. Developmental studies have demonstrated such a relationship, but to 
      date no studies have examined colocalization of estrogen receptors and BDNF 
      within the adult brain. By utilizing double-label immunohistochemistry for BDNF, 
      estrogen receptor-alpha (ER-alpha), and estrogen receptor-beta (ER-beta), we 
      found only sparse colocalization between ER-alpha and BDNF in the hypothalamus, 
      amygdala, prelimbic cortex, and ventral hippocampus. Furthermore, ER-beta and 
      BDNF do not colocalize in any brain region. Given the recent finding that 
      cortical ER-beta is almost exclusively localized to parvalbumin-immunoreactive 
      GABAergic neurons, we performed BDNF/parvalbumin double labeling and discovered 
      that axons from cortical ER-beta-expressing inhibitory neurons terminate on 
      BDNF-immunoreactive pyramidal cells. Collectively, these findings support a 
      potential transsynaptic relationship between estrogen state and cortical BDNF: By 
      directly modulating GABAergic interneurons, estrogen may indirectly influence the 
      activity and expression of BDNF-producing cortical neurons.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Blurton-Jones, M
AU  - Blurton-Jones M
AD  - Department of Neurosciences, University of California-San Diego, La Jolla, 
      California 92093-0626, USA.
FAU - Kuan, P N
AU  - Kuan PN
FAU - Tuszynski, M H
AU  - Tuszynski MH
LA  - eng
GR  - 2 T32 AG00216/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Estrogens)
RN  - 0 (Parvalbumins)
RN  - 0 (Receptors, Estrogen)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Amygdala/chemistry
MH  - Animals
MH  - *Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor/*analysis/metabolism
MH  - Estrogen Receptor alpha
MH  - Estrogen Receptor beta
MH  - Estrogens/metabolism
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Hippocampus/chemistry
MH  - Hypothalamus/chemistry
MH  - Immunohistochemistry
MH  - Interneurons/*chemistry/metabolism
MH  - Neocortex/*chemistry/metabolism
MH  - Parvalbumins/analysis
MH  - Pyramidal Cells/*chemistry/metabolism
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, Estrogen/*analysis/metabolism
MH  - gamma-Aminobutyric Acid
EDAT- 2003/12/19 05:00
MHDA- 2004/03/27 05:00
CRDT- 2003/12/19 05:00
PHST- 2003/12/19 05:00 [pubmed]
PHST- 2004/03/27 05:00 [medline]
PHST- 2003/12/19 05:00 [entrez]
AID - 10.1002/cne.10989 [doi]
PST - ppublish
SO  - J Comp Neurol. 2004 Jan 12;468(3):347-60. doi: 10.1002/cne.10989.