PMID- 14682395
OWN - NLM
STAT- MEDLINE
DCOM- 20041116
LR  - 20061115
IS  - 0145-5680 (Print)
IS  - 0145-5680 (Linking)
VI  - 49
IP  - 7
DP  - 2003 Nov
TI  - Characterization and function of the multifaceted peripheral blood basophil.
PG  - 1125-35
AB  - Basophils are derived from metachromatic hematopoietic precursor cells of myeloid 
      origin. The basophilic granulocyte differentiates and matures in the bone marrow, 
      circulates in the peripheral blood, and upon proper stimulation, migrates into 
      the tissues. Peripheral blood basophils act as chief effector cells of the 
      allergic response and as purveyors of various allergy-associated mediators. Under 
      appropriate conditions, basophils can be induced to release their mediators into 
      the extracellular space of tissues or blood of the host organism. The plasma 
      membrane of basophils contains receptors for immunoglobulin E (IgE) 
      homocytotropic antibody which exhibits high affinity for these granulocytes and 
      their Fc epsilon receptors. IgE cytophilic antibody binds antigen at its Fab 
      portion. When bound to the basophil plasma membrane, the antigen-antibody complex 
      undergoes multivalent interactions, which create crosslinking of the Fc epsilon 
      receptors on the basophil plasma membrane. This receptor cross-linking results in 
      basophil degranulation and subsequent release of its pharmacologically active 
      substances. The basophil exhibits considerable heterogeneity and is characterized 
      as Type I, II, III, IV, V and VI based upon granule content and time of antigen 
      stimulation. Evidence is presented showing the role of the basophil in 
      hyperplasia, hypersensitivity, parasitic infections and other diseases.
FAU - Uston, P I
AU  - Uston PI
AD  - Department of Biology, Howard University, 415 College Street, NW, Washington, DC 
      20059, USA.
FAU - Lee, C M
AU  - Lee CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Basophils/cytology/immunology/*metabolism
MH  - Bone Marrow Cells/cytology/metabolism
MH  - Histamine Release/*immunology/physiology
MH  - Humans
MH  - Hypersensitivity/*metabolism
MH  - Immunoglobulin E/immunology/*metabolism
MH  - Receptors, IgE/immunology/*metabolism
RF  - 64
EDAT- 2003/12/20 05:00
MHDA- 2004/11/17 09:00
CRDT- 2003/12/20 05:00
PHST- 2003/12/20 05:00 [pubmed]
PHST- 2004/11/17 09:00 [medline]
PHST- 2003/12/20 05:00 [entrez]
PST - ppublish
SO  - Cell Mol Biol (Noisy-le-grand). 2003 Nov;49(7):1125-35.