PMID- 14684181
OWN - NLM
STAT- MEDLINE
DCOM- 20040210
LR  - 20220225
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 313
IP  - 2
DP  - 2004 Jan 9
TI  - Raptor, a binding partner of target of rapamycin.
PG  - 437-41
AB  - The mammalian target of rapamycin (mTOR) controls cell growth in response to 
      amino acids and growth factors, in part by regulating p70 S6 kinase alpha (p70 
      alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor 
      (regulatory associated protein of mTOR) is a 150 kDa mTOR binding protein that is 
      essential for TOR signaling in vivo and also binds 4EBP1 and p70alpha through 
      their respective TOS (TOR signaling) motifs, a short conserved segment previously 
      shown to be required for amino acid- and mTOR-dependent regulation of these 
      substrates in vivo. Raptor appears to serve as an mTOR scaffold protein, the 
      binding of which to the TOS motif of mTOR substrates is necessary for effective 
      mTOR-catalyzed phosphorylation. Further understanding of regulation of the 
      mTOR-raptor complex in response to the nutritional environment would require 
      identification of the interplay between the mTOR-raptor complex and its upstream 
      effectors such as the protein products of tumor suppressor gene tuberous 
      sclerosis complexes 1 and 2, and the Ras-related small G protein Rheb.
FAU - Yonezawa, Kazuyoshi
AU  - Yonezawa K
AD  - Biosignal Research Center, Kobe University, Kobe 657-8501, Japan. 
      yonezawa@kobe-u.ac.jp
FAU - Tokunaga, Chiharu
AU  - Tokunaga C
FAU - Oshiro, Noriko
AU  - Oshiro N
FAU - Yoshino, Ken-ichi
AU  - Yoshino K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (EIF4EBP1 protein, human)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proteins)
RN  - 0 (RPTOR protein, human)
RN  - 0 (Regulatory-Associated Protein of mTOR)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/metabolism
MH  - Cell Cycle Proteins
MH  - Conserved Sequence
MH  - Humans
MH  - Molecular Sequence Data
MH  - Phosphoproteins/metabolism
MH  - Phosphorylation
MH  - Protein Kinases/*metabolism
MH  - Proteins/chemistry/genetics/*metabolism
MH  - Regulatory-Associated Protein of mTOR
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - TOR Serine-Threonine Kinases
RF  - 35
EDAT- 2003/12/20 05:00
MHDA- 2004/02/11 05:00
CRDT- 2003/12/20 05:00
PHST- 2003/12/20 05:00 [pubmed]
PHST- 2004/02/11 05:00 [medline]
PHST- 2003/12/20 05:00 [entrez]
AID - S0006291X03023453 [pii]
AID - 10.1016/j.bbrc.2003.07.018 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2004 Jan 9;313(2):437-41. doi: 
      10.1016/j.bbrc.2003.07.018.