PMID- 14685899
OWN - NLM
STAT- MEDLINE
DCOM- 20040406
LR  - 20220311
IS  - 0167-6830 (Print)
IS  - 0167-6830 (Linking)
VI  - 22
IP  - 4
DP  - 2003 Dec
TI  - Expression of HLA class I, beta(2)-microglobulin and HLA class II antigens in 
      primary orbital melanoma.
PG  - 257-63
AB  - Major histocompatibility antigens (MHC) play a crucial role in the recognition of 
      tumor cells by the immune system. There is not much information on the role of 
      MHC molecule expression in primary orbital melanomas. In the present study, the 
      authors examined the expression of human leukocyte antigen (HLA) class I, 
      beta(2)-microglobulin (beta(2)-m) and HLA class II antigens in primary orbital 
      melanoma and correlated this with the clinical and pathological findings. HLA 
      class I antigen, beta(2)-m and HLA class II antigen expression were evaluated 
      immunohistochemically in three primary orbital melanomas and correlated with cell 
      type and metastasis. Immunohistochemistry showed heterogeneous expression of HLA 
      class I, beta(2)-m and HLA class II antigen in two cases with no liver metastasis 
      and negative expression in one case with liver metastasis. This preliminary 
      observation deserves further investigation, which may shed more light on the 
      immune escape mechanisms of this tumor and thus make possible novel therapeutic 
      strategies.
FAU - Krishnakumar, Subramanian
AU  - Krishnakumar S
AD  - Ocular Pathology laboratory, Medical and Vision Research Foundations, Chennai, 
      Sankara Nethralaya, India.
FAU - Lakshmi, Sundaram
AU  - Lakshmi S
FAU - Abhyankar, Dhiraj
AU  - Abhyankar D
FAU - Biswas, Jyotirmay
AU  - Biswas J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Orbit
JT  - Orbit (Amsterdam, Netherlands)
JID - 8301221
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - Female
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Histocompatibility Antigens Class II/*metabolism
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Melanoma/*metabolism
MH  - Orbital Neoplasms/*metabolism
MH  - beta 2-Microglobulin/*metabolism
EDAT- 2003/12/20 05:00
MHDA- 2004/04/07 05:00
CRDT- 2003/12/20 05:00
PHST- 2003/12/20 05:00 [pubmed]
PHST- 2004/04/07 05:00 [medline]
PHST- 2003/12/20 05:00 [entrez]
AID - 10.1076/orbi.22.4.257.17242 [doi]
PST - ppublish
SO  - Orbit. 2003 Dec;22(4):257-63. doi: 10.1076/orbi.22.4.257.17242.