PMID- 14690140
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20220317
IS  - 0300-9742 (Print)
IS  - 0300-9742 (Linking)
VI  - 32
IP  - 5
DP  - 2003
TI  - HLA-DRB1 genes and disease severity in rheumatoid arthritis in Turkey.
PG  - 277-80
AB  - OBJECTIVE: Association with human leukocyte antigen (HLA)-DRB alleles, implicated 
      in the aetiopathogenesis of rheumatoid arthritis (RA), is found to be different 
      in various ethnic groups. This study aimed to investigate DRB1 alleles in RA 
      patients in Turkey, and to examine the effect of these alleles on disease 
      severity. METHODS: We performed PCR-based DRBI genotyping of 104 RA patients 
      recruited from clinical settings and 110 healthy controls. HLA DRB1 alleles 
      frequencies in RA patients and healthy controls were determined. Phenotype 
      frequencies of patients and controls were compared. Disease severity was assessed 
      by radiological erosion, presence of extra-articular involvement, and functional 
      index. RESULTS: Significant differences were in the frequencies of DRB1*04 (46.2% 
      versus 20.9%, p < 0.001), DRB1*0401 (10.6% versus 0%, p < 0.001), DRB1*0405 (8.7% 
      versus 0%, p = 0.001), DRB1* 0404 (15.4% versus 3.6%, p < 0.01), DRB1*01 (21.2% 
      versus 10.9%, p < 0.05) and DRB1*0101 (16.3% versus 5.5%, p = 0.01) between RA 
      patients and controls. HLA-DRB1 alleles did not show any association with 
      seropositivity, extra-articular involvement, radiological erosion, or functional 
      index. CONCLUSION: Our results suggest that the HLA-DRB1 alleles, particularly 
      HLA-DRB1*04 and subtypes, were associated with RA.
FAU - Kinikli, G
AU  - Kinikli G
AD  - Department of Clinical Immunology and Rheumatology, Ankara University Medical 
      School, Ankara, Turkey.
FAU - Ates, A
AU  - Ates A
FAU - Turgay, M
AU  - Turgay M
FAU - Akay, G
AU  - Akay G
FAU - Kinikli, S
AU  - Kinikli S
FAU - Tokgoz, G
AU  - Tokgoz G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:01 antigen)
SB  - IM
MH  - Activities of Daily Living
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/epidemiology/*genetics/*physiopathology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genome, Human
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Severity of Illness Index
MH  - Turkey/epidemiology
EDAT- 2003/12/24 05:00
MHDA- 2004/01/07 05:00
CRDT- 2003/12/24 05:00
PHST- 2003/12/24 05:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/12/24 05:00 [entrez]
AID - 10.1080/03009740310003901 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 2003;32(5):277-80. doi: 10.1080/03009740310003901.