PMID- 14690526
OWN - NLM
STAT- MEDLINE
DCOM- 20040217
LR  - 20220330
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 88
IP  - 2
DP  - 2004 Jan
TI  - Identification of differentially regulated transcripts in mouse striatum 
      following methamphetamine treatment--an oligonucleotide microarray approach.
PG  - 380-93
AB  - Methamphetamine is an addictive drug of abuse that can produce neurotoxic effects 
      in dopamine nerve endings of the striatum. The purpose of this study was to 
      identify new genes that may play a role in the highly complex cascade of events 
      associated with methamphetamine intoxication. Using Affymetrix oligonucleotide 
      arrays, 12 488 genes were simultaneously interrogated and there were 152 whose 
      expression levels were changed following methamphetamine treatment. The genes are 
      grouped into broad functional categories with inflammatory/immune response 
      elements, receptor/signal transduction components and ion channel/transport 
      proteins among the most populated. Many genes within these categories can be 
      linked to ion regulation and apoptosis, both of which have been implicated in 
      methamphetamine toxicity, and numerous factors associated with microglial 
      activation emerged with significant changes in expression. For example, 
      brain-derived neurotrophic factor (BDNF), chemokine (C-C) receptor 6 (CCr6) and 
      numerous chemokine transcripts were increased or decreased in expression more 
      than 2.8-fold. These results point to activated microglia as a potential source 
      of the reactive oxygen/nitrogen species and cytokines that have been previously 
      associated with methamphetamine toxicity and other neurotoxic conditions.
FAU - Thomas, David M
AU  - Thomas DM
AD  - Department of Psychiatry and Behavioral Neurosciences, Wayne State University 
      School of Medicine, Detroit, Michigan 48201, USA.
FAU - Francescutti-Verbeem, Dina M
AU  - Francescutti-Verbeem DM
FAU - Liu, Xiuli
AU  - Liu X
FAU - Kuhn, Donald M
AU  - Kuhn DM
LA  - eng
GR  - DA13753/DA/NIDA NIH HHS/United States
GR  - DA14692/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain Chemistry/*drug effects/*genetics
MH  - Corpus Striatum/*drug effects/*metabolism
MH  - Gene Expression Profiling/methods
MH  - Male
MH  - Methamphetamine/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Oligonucleotide Array Sequence Analysis/*methods
MH  - Transcription, Genetic/*drug effects/physiology
EDAT- 2003/12/24 05:00
MHDA- 2004/02/18 05:00
CRDT- 2003/12/24 05:00
PHST- 2003/12/24 05:00 [pubmed]
PHST- 2004/02/18 05:00 [medline]
PHST- 2003/12/24 05:00 [entrez]
AID - 2182 [pii]
AID - 10.1046/j.1471-4159.2003.02182.x [doi]
PST - ppublish
SO  - J Neurochem. 2004 Jan;88(2):380-93. doi: 10.1046/j.1471-4159.2003.02182.x.