PMID- 14693734
OWN - NLM
STAT- MEDLINE
DCOM- 20040423
LR  - 20220317
IS  - 1055-9965 (Print)
IS  - 1055-9965 (Linking)
VI  - 12
IP  - 12
DP  - 2003 Dec
TI  - Meningioma: is there an association with human leukocyte antigens?
PG  - 1438-42
AB  - The expression of human leukocyte antigen (HLA) alleles plays an important role 
      in the development and recurrence of benign and malignant diseases. Association 
      of single HLA alleles or haplotypes with neoplastic processes has been 
      investigated previously, and correlation between HLA and solid tumors, such as 
      head and neck cancers or uterine cervical squamous epithelial lesions, were 
      reported. However, there is no published data on the influence of the HLA system 
      on the development of symptomatic cerebral meningioma, a mostly benign 
      intracranial tumor of mesenchymal origin in adults. The present investigation is 
      comparing the frequency of single HLA alleles and haplotypes in 81 adult 
      Caucasian patients with symptomatic central nervous system meningiomas to that of 
      157 area- and race-matched healthy controls. Both standard serological and 
      molecular genetic (PCR) techniques were used for HLA typing. Our results suggest 
      an association between single HLA alleles and occurrence of clinically 
      symptomatic meningioma. Patients with HLA-A*02 had a 2.5-fold increased risk of 
      meningioma (P = 0.02), and those with HLA-DQB1*05 had a 1.8-fold increased risk 
      of meningioma (P = 0.05). Conversely, HLA-A*01, -B*08, and -DRB1*03 were 
      associated with a 0.4-, 0.5-, and 0.5-fold, respectively, decreased risk of 
      meningioma (P = 0.008, P = 0.05, and P = 0.04). Moreover, the occurrence rate of 
      combinations and estimated haplotypes containing these HLA alleles was strikingly 
      different in meningioma patients compared with controls: significantly increased 
      for the haplotypes HLA-A*02:DRB1*04 (P = 0.02, relative risk = 2.5) and 
      HLA-A*02:DRB1*04:DQB1*0302,DQB1*05 (P = 0.03, RR = 7.5), and significantly 
      decreased for the haplotype HLA-A*01:B*08:DRB1*03 (P = 0.01, relative risk = 
      0.2). In conclusion, these data suggest that some single HLA alleles and 
      haplotypes may protect from or predispose to developing symptomatic central 
      nervous system meningioma during adult life. These associations may be indicative 
      of the involvement of the immune system in the host antitumor surveillance, 
      recognition, and destruction of de novo arising human tumor cells.
FAU - Machulla, Helmut K G
AU  - Machulla HK
AD  - Interbranch Human Leukocyte Antigen Laboratory, Institute of Medical Immunology, 
      Martin-Luther University, Halle, Germany.
FAU - Steinborn, Frank
AU  - Steinborn F
FAU - Tschigrjai, Michail
AU  - Tschigrjai M
FAU - Langner, Jurgen
AU  - Langner J
FAU - Rainov, Nikolai G
AU  - Rainov NG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Meningeal Neoplasms/epidemiology/*genetics/immunology
MH  - Meningioma/epidemiology/*genetics/immunology
MH  - Middle Aged
MH  - Probability
MH  - Prospective Studies
MH  - Reference Values
MH  - Sensitivity and Specificity
EDAT- 2003/12/25 05:00
MHDA- 2004/04/24 05:00
CRDT- 2003/12/25 05:00
PHST- 2003/12/25 05:00 [pubmed]
PHST- 2004/04/24 05:00 [medline]
PHST- 2003/12/25 05:00 [entrez]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2003 Dec;12(12):1438-42.