PMID- 14693917 OWN - NLM STAT- MEDLINE DCOM- 20041221 LR - 20111117 IS - 0959-6658 (Print) IS - 0959-6658 (Linking) VI - 14 IP - 4 DP - 2004 Apr TI - Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor. PG - 357-63 AB - Brain-derived neurotrophic factor (BDNF) is a neuroprotective polypeptide that is thought to be responsible for neuron proliferation, differentiation, and survival. An agent that enhances production of BDNF is expected to be useful for the treatment of neurodegenerative diseases. Here we report that galectin-1, a member of the family of beta-galactoside binding proteins, induces astrocyte differentiation and strongly inhibits astrocyte proliferation, and then the differentiated astrocytes greatly enhance their production of BDNF. Induction of astrocyte differentiation and BDNF production by an endogenous mammalian lectin may be a new mechanism for preventing neuronal loss after injury. FAU - Sasaki, Tasuku AU - Sasaki T AD - Glycobiology Research Group, Tokyo Metropolitan Institute of Gerontology, Foundation for Research on Aging and Promotion of Human Welfare, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan. FAU - Hirabayashi, Jun AU - Hirabayashi J FAU - Manya, Hiroshi AU - Manya H FAU - Kasai, Ken-ichi AU - Kasai K FAU - Endo, Tamao AU - Endo T LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20031223 PL - England TA - Glycobiology JT - Glycobiology JID - 9104124 RN - 0 (Asialoglycoproteins) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Fetuins) RN - 0 (Galectin 1) RN - 0 (alpha-Fetoproteins) RN - 0 (asialofetuin) RN - 21820-51-9 (Phosphotyrosine) SB - IM MH - Animals MH - Asialoglycoproteins/metabolism MH - Astrocytes/*cytology/*drug effects/metabolism MH - Brain Chemistry/drug effects MH - Brain-Derived Neurotrophic Factor/*biosynthesis/immunology/metabolism MH - Cell Differentiation/*drug effects MH - Cell Proliferation/drug effects MH - Cell Shape/drug effects MH - Cells, Cultured MH - Electrophoresis, Polyacrylamide Gel MH - Female MH - Fetuins MH - Galectin 1/*pharmacology MH - Humans MH - Immunoblotting MH - Phosphorylation MH - Phosphotyrosine/immunology/metabolism MH - Rats MH - Rats, Inbred F344 MH - Signal Transduction/drug effects MH - alpha-Fetoproteins/metabolism EDAT- 2003/12/25 05:00 MHDA- 2004/12/22 09:00 CRDT- 2003/12/25 05:00 PHST- 2003/12/25 05:00 [pubmed] PHST- 2004/12/22 09:00 [medline] PHST- 2003/12/25 05:00 [entrez] AID - cwh043 [pii] AID - 10.1093/glycob/cwh043 [doi] PST - ppublish SO - Glycobiology. 2004 Apr;14(4):357-63. doi: 10.1093/glycob/cwh043. Epub 2003 Dec 23.