PMID- 14695476
OWN - NLM
STAT- MEDLINE
DCOM- 20040723
LR  - 20161124
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 55
IP  - 6
DP  - 2003 Dec 25
TI  - Regulation of neuromuscular transmission by neurotrophins.
PG  - 617-24
AB  - Motor units comprise a motoneuron and the muscle fibers it innervates. 
      Neuromuscular transmission is tightly regulated to match the activity of 
      individual motor units. Activity-dependent release of neuromodulators at the 
      neuromuscular junction (NMJ) determines the efficacy of transmission. The 
      neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) 
      are produced by motoneurons and muscle fibers, and their release by skeletal 
      muscle is regulated by muscle activity. BDNF and NT-4 enhance both spontaneous 
      and evoked synaptic transmission at NMJs via activation of the tyrosine kinase 
      receptor B (TrkB). Improvements in neuromuscular transmission may result from 
      increased release of synaptic vesicles, either by presynaptic alterations in 
      Ca(2+) transients or facilitated vesicular exocytosis. In fact, BDNF potentiates 
      intracellular Ca(2+) release presynaptically and BDNF-induced TrkB activation 
      also results in phosphorylation of synapsin I via mitogen activated protein 
      kinase, which increases the number of synaptic vesicles available for release. 
      Neurotrophins may also regulate synaptic transmission at the NMJ by increasing 
      local release of neuregulin or other nerve-derived modulators. We review recent 
      studies on the regulation of neuromuscular transmission, the motor unit-specific 
      properties of NMJs and the effects of neurotrophins on synaptic efficacy at the 
      NMJ.
FAU - Zhan, Wen-Zhi
AU  - Zhan WZ
AD  - Department of Anesthesiology, Mayo Clinic and Foundation Rochester, MN 55905, 
      USA. zhan.wenzhi@mayo.edu
FAU - Mantilla, Carlos B
AU  - Mantilla CB
FAU - Sieck, Gary C
AU  - Sieck GC
LA  - eng
GR  - HL34817/HL/NHLBI NIH HHS/United States
GR  - HL37680/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Synapsins)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - P658DCA9XD (neurotrophin 4)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Calcium/metabolism
MH  - Humans
MH  - Nerve Growth Factors/*physiology
MH  - Neuromuscular Junction/*physiology
MH  - Neuronal Plasticity
MH  - Receptor, trkB/*metabolism
MH  - Synapses/metabolism
MH  - Synapsins/metabolism
MH  - Synaptic Vesicles
RF  - 67
EDAT- 2003/12/26 05:00
MHDA- 2004/07/24 05:00
CRDT- 2003/12/26 05:00
PHST- 2003/12/26 05:00 [pubmed]
PHST- 2004/07/24 05:00 [medline]
PHST- 2003/12/26 05:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 2003 Dec 25;55(6):617-24.