PMID- 14695996
OWN - NLM
STAT- MEDLINE
DCOM- 20040218
LR  - 20081121
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 39
IP  - 2
DP  - 2004 Feb
TI  - Clonal variation of the immunogenotype in relapsed ETV6/RUNX1-positive acute 
      lymphoblastic leukemia indicates subclone formation during early stages of 
      leukemia development.
PG  - 156-60
AB  - Recent data suggest that late relapses evolve from an ancestral 
      ETV6/RUNX1-positive (also designated TEL/AML1-positive) clone resulting from 
      secondary changes (ETV6 deletion) that differ from those of the initial leukemia 
      and, as a consequence, may also deviate in their clonotypic immunoglobulin/T-cell 
      receptor (IG/TCR) gene rearrangements. The aim of our study was to compare the 
      immunogenotype and fluorescence in situ hybridization (FISH) patterns of the 
      unrearranged ETV6 allele of matched diagnosis/relapse samples from 12 children 
      with an early or late relapse. We identified varying degrees of differences in 
      the IG/TCR in six of them. A clonal change or evolution of the unrearranged ETV6 
      allele was also observed in six children but remained unchanged in three. 
      However, these two parameters were not in concordance, nor did the immunogenotype 
      pattern correlate with the duration of the first remission. We therefore propose 
      that the potential of the immunogenotype to diversify depends primarily on the 
      stage of IG/TCR gene configuration of the cell in which the ETV6/RUNX1 gene 
      fusion takes place.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Peham, Martina
AU  - Peham M
AD  - Children's Cancer Research Institute, A-1090 Vienna, Austria.
FAU - Konrad, Marianne
AU  - Konrad M
FAU - Harbott, Jochen
AU  - Harbott J
FAU - Konig, Margit
AU  - Konig M
FAU - Haas, Oskar A
AU  - Haas OA
FAU - Panzer-Grumayer, E Renate
AU  - Panzer-Grumayer ER
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 0 (TEL-AML1 fusion protein)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Core Binding Factor Alpha 2 Subunit
MH  - Gene Rearrangement/genetics
MH  - Genes, Immunoglobulin/*genetics
MH  - Genetic Variation/*genetics
MH  - Genotype
MH  - Humans
MH  - Infant
MH  - Neoplasm Recurrence, Local/genetics
MH  - Neoplasm Staging
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Receptors, Antigen, T-Cell, gamma-delta/genetics
MH  - Translocation, Genetic/genetics
EDAT- 2003/12/30 05:00
MHDA- 2004/02/19 05:00
CRDT- 2003/12/30 05:00
PHST- 2003/12/30 05:00 [pubmed]
PHST- 2004/02/19 05:00 [medline]
PHST- 2003/12/30 05:00 [entrez]
AID - 10.1002/gcc.10305 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2004 Feb;39(2):156-60. doi: 10.1002/gcc.10305.