PMID- 14697640
OWN - NLM
STAT- MEDLINE
DCOM- 20040304
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 148
IP  - 1
DP  - 2004 Jan 1
TI  - Molecular cytogenetic abnormalities in patients with concurrent chronic 
      lymphocytic leukemia and multiple myeloma shown by interphase fluorescence in 
      situ hybridization: evidence of distinct clonal origin.
PG  - 44-8
AB  - The coexistence of chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) 
      is rare, and there is no consensus about the clonal relationship of the two 
      disorders when they occur in the same individual. We investigated chromosomal 
      abnormalities in two patients with concurrent CLL and MM using interphase 
      fluorescence in situ hybridization (FISH) with a panel of region-specific DNA 
      probes. In patient 1, the clonal plasma cells harbored IgH translocations 
      (14q32); however, FISH with probes for the four most frequent IgH partner genes 
      in MM (CCND1, FGFR3, MAF, and MYC) did not detect translocations involving any of 
      them. The CLL cells were characterized by deletions of 13q14, 11q23, and 17p13, 
      as well as trisomy 12, none of which were found in the MM cells. In patient 2, 
      deletions of 13q14 and 17p13 were detected in CLL cells, but no cytogenetic 
      abnormalities were found in the MM cells. Both patients had relapsed MM following 
      chemotherapy and had autologous stem-cell transplant, whereas their CLL has been 
      stable and not requiring treatment. Our results show that the cytogenetic 
      profiles differ between CLL and MM within the same patients, and provide evidence 
      for two distinct malignant clones in both patients.
FAU - Chang, Hong
AU  - Chang H
AD  - Department of Laboratory Hematology, Princess Margaret Hospital and University 
      Health Network, University of Toronto, 610 University Avenue, 4-320, Toronto, 
      Ontario M5G 2M9, Canada. hong.chang@uhn.on.ca
FAU - Wechalekar, Ashutosh
AU  - Wechalekar A
FAU - Li, Linda
AU  - Li L
FAU - Reece, Donna
AU  - Reece D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - *Interphase
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics
EDAT- 2003/12/31 05:00
MHDA- 2004/03/05 05:00
CRDT- 2003/12/31 05:00
PHST- 2003/12/31 05:00 [pubmed]
PHST- 2004/03/05 05:00 [medline]
PHST- 2003/12/31 05:00 [entrez]
AID - S0165460803002176 [pii]
AID - 10.1016/s0165-4608(03)00217-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2004 Jan 1;148(1):44-8. doi: 
      10.1016/s0165-4608(03)00217-6.