PMID- 14698652
OWN - NLM
STAT- MEDLINE
DCOM- 20041214
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 111
IP  - 6
DP  - 2003
TI  - Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients 
      with arterial and venous thrombosis from North Western Russia.
PG  - 351-6
AB  - Conflicting data from Western European and USA population studies led us to 
      investigate hyperhomocysteinemia (HHcy), the methylenetetrahydrofolate reductase 
      (MTHFR) C677T polymorphisms and thrombotic disease in North Western Russia. 
      Plasma total homocysteine (tHcy) levels, MTHFR C677T genotype, selected life 
      style determinants and haemostatic factor activity were determined in patients 
      with arterial (n = 33), venous (n = 40), arterial + venous (n = 11) thrombosis 
      and healthy controls (n = 30). We found raised median tHcy levels in all patient 
      groups vs. controls (p < 0.05), with odds ratios (95% CI) for vascular disease 
      among patients with HHcy (defined as > 15 micromol/l) of 3.9 (0.6 - 14.3), 4.8 
      (1.2 - 18.8) and 15.8 (2.8 - 87.3) respectively. tHcy levels were a function of 
      MTHFR C677T genotype, and all patients with tHcy levels > 30 micromol/l had the 
      MTHFR C677T homozygous substitution. Elevated tHcy levels (p < 0.05) were 
      identified in smokers and coffee drinkers, with the degree of elevation dependent 
      on MTHFR C677T genotype. Of the studied haemostatic parameters increased factor 
      VIII activity and vWF antigen and activity was observed in HHcy subjects. We 
      conclude that HHcy and MTHFR C677T genotype are positively associated with 
      arterial and venous thrombotic disease in the population of North Western Russia.
FAU - Shmeleva, Veronika M
AU  - Shmeleva VM
AD  - Russian Institute of Haematology and Transfusion, St. Petersburg, 2-nd 
      Sovietskaya 16, Russia. papayan@mail.ru
FAU - Kapustin, Sergey I
AU  - Kapustin SI
FAU - Papayan, Ludmila P
AU  - Papayan LP
FAU - Sobczynska-Malefora, Agata
AU  - Sobczynska-Malefora A
FAU - Harrington, Dominic J
AU  - Harrington DJ
FAU - Savidge, Geoffrey F
AU  - Savidge GF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Coagulation
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/complications/enzymology/epidemiology/*genetics
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Mutation
MH  - Polymorphism, Genetic
MH  - Retrospective Studies
MH  - Russia/epidemiology
MH  - Thrombosis/complications/epidemiology/genetics
MH  - Venous Thrombosis/complications/epidemiology/genetics
EDAT- 2003/12/31 05:00
MHDA- 2004/12/16 09:00
CRDT- 2003/12/31 05:00
PHST- 2003/12/31 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2003/12/31 05:00 [entrez]
AID - S0049384803005322 [pii]
AID - 10.1016/j.thromres.2003.10.004 [doi]
PST - ppublish
SO  - Thromb Res. 2003;111(6):351-6. doi: 10.1016/j.thromres.2003.10.004.