PMID- 14698864
OWN - NLM
STAT- MEDLINE
DCOM- 20040302
LR  - 20190827
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 146
IP  - 1-2
DP  - 2004 Jan
TI  - Induction of beta-chemokine secretion by human brain microvessel endothelial 
      cells via CD40/CD40L interactions.
PG  - 203-8
AB  - beta-chemokines play an important role during the course of central nervous 
      system (CNS) inflammation. Using primary cultures of human cerebral microvascular 
      endothelial cells, we detected increased monocyte chemoattractant protein-1 
      (MCP-1) and regulated upon activation normal T cell expressed and secreted 
      (RANTES) production following incubation with soluble CD40L. These results 
      suggest a potential mechanism by which activated CD40L positive T cells may 
      enhance beta-chemokine expression and thus influence the recruitment of 
      mononuclear cells across the human blood-brain barrier.
FAU - Omari, Kakuri M
AU  - Omari KM
AD  - Neuropathology Research Laboratory, Department of Pathology and Laboratory 
      Medicine, Vancouver General Hospital and the University of British Columbia, 855 
      West 12th Avenue, Vancouver, BC, Canada V5Z 1M9.
FAU - Chui, Raymond
AU  - Chui R
FAU - Dorovini-Zis, Katerina
AU  - Dorovini-Zis K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (CD40 Antigens)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines, CC)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Brain/drug effects/immunology/*metabolism
MH  - CD40 Antigens/*metabolism/physiology
MH  - CD40 Ligand/*metabolism/physiology
MH  - Chemokine CCL2/pharmacology
MH  - Chemokine CCL5/pharmacology
MH  - Chemokines, CC/*metabolism
MH  - Endothelial Cells/immunology/*metabolism
MH  - Humans
MH  - Microcirculation/immunology/metabolism
EDAT- 2003/12/31 05:00
MHDA- 2004/03/03 05:00
CRDT- 2003/12/31 05:00
PHST- 2003/12/31 05:00 [pubmed]
PHST- 2004/03/03 05:00 [medline]
PHST- 2003/12/31 05:00 [entrez]
AID - S0165572803004557 [pii]
AID - 10.1016/j.jneuroim.2003.10.032 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2004 Jan;146(1-2):203-8. doi: 10.1016/j.jneuroim.2003.10.032.