PMID- 14700591
OWN - NLM
STAT- MEDLINE
DCOM- 20040909
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 1
DP  - 2004 Jan
TI  - The HLA-DR phenotype of the responder is predictive of humoral response against 
      HLA class I antigens.
PG  - 13-9
AB  - Recent studies suggest that the immunogenicity of an human leukocyte antigen 
      (HLA) incompatibility should be considered in the context of the HLA phenotype of 
      the recipient. The HLA-DR phenotype of the responder is thought to be predictive 
      for the strength of the alloimmune response. In order to analyze the humoral 
      response against HLA class I antigens in the context of the HLA-DR phenotype of 
      the responder, we selected all HLA-DR homozygous Dutch patients that were present 
      on the Eurotransplant waiting list between 1967 and 2000 (n=1,317 patients). By 
      logistic regression it was determined whether antibody production against a 
      specific HLA class I antigen is associated with a particular HLA-DR antigen in 
      the patient. Furthermore, it was analyzed whether a patient, expressing a 
      particular HLA-DR antigen, preferentially produces antibodies against particular 
      HLA class I antigens. The results demonstrate that patients, homozygous for a 
      certain HLA-DR antigen, cannot be considered high or low responders when 
      analyzing the antibody response in terms of panel reactive antibody (PRA) value. 
      However, a correlation can be found between the HLA-DR phenotype of the patient 
      and the specific antibody response against HLA class I antigens. For example, 
      antibodies against HLA-A10, -A11, -A19, and -B35 are produced more frequently by 
      HLA-DR6 positive individuals, whereas antibodies against HLA-A3, -B5, -B7, -B8, 
      and -B12 are produced more frequently by HLA-DR4 positive individuals. These data 
      confirm that the HLA-DR phenotype of the responder plays a determinative role in 
      the immunogenicity of mismatched HLA antigens. The results indicate that 
      selection of HLA class I mismatches of the donor in the context of the HLA-DR 
      phenotype of the responder might reduce the incidence of humoral graft rejection 
      and minimize the sensitization grade of retransplant candidates.
FAU - Dankers, Marlies K A
AU  - Dankers MK
AD  - Department of Immunohematology and Blood Transfusion, Leiden University, Leiden, 
      The Netherlands. m.k.a.dankers@lumc.nl
FAU - Roelen, Dave L
AU  - Roelen DL
FAU - Nagelkerke, Nico J D
AU  - Nagelkerke NJ
FAU - de Lange, Peter
AU  - de Lange P
FAU - Persijn, Guido G
AU  - Persijn GG
FAU - Doxiadis, Ilias I N
AU  - Doxiadis II
FAU - Claas, Frans H J
AU  - Claas FH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Antibody Formation
MH  - Cohort Studies
MH  - Genotype
MH  - HLA-A Antigens/*immunology
MH  - HLA-B Antigens/*immunology
MH  - HLA-DR Antigens/*analysis/immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Isoantibodies/*biosynthesis/blood
MH  - Kidney Transplantation/*immunology
MH  - Predictive Value of Tests
EDAT- 2004/01/01 05:00
MHDA- 2004/09/10 05:00
CRDT- 2004/01/01 05:00
PHST- 2004/01/01 05:00 [pubmed]
PHST- 2004/09/10 05:00 [medline]
PHST- 2004/01/01 05:00 [entrez]
AID - S0198885903005895 [pii]
AID - 10.1016/j.humimm.2003.09.017 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Jan;65(1):13-9. doi: 10.1016/j.humimm.2003.09.017.