PMID- 14700594
OWN - NLM
STAT- MEDLINE
DCOM- 20040909
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 1
DP  - 2004 Jan
TI  - HLA-G is associated with pemphigus vulgaris in Jewish patients.
PG  - 39-46
AB  - Pemphigus is a group of life-threatening autoimmune blistering diseases of the 
      skin and mucous membranes. The etiology and pathogenesis of this destructive 
      autoimmune process remains unknown, but significant association with human 
      leukocyte antigen (HLA) factors have been described in pemphigus vulgaris (PV) 
      patient cohorts worldwide. We have recently analyzed DNA samples obtained from 
      pemphigus patients and matched controls with a set of microsatellite markers, and 
      found that markers mapped to HLA class I region are significantly associated with 
      the disease. In order to narrow the region that is associated with the disease 
      single nucleotide polymorphism (SNP) technology was used. In this study, a set of 
      26 SNP markers, which span a chromosomal region of about 600,000 bp, were used to 
      screen DNA samples of the patients and their matched controls. Of the 26 SNPs, 
      four markers were found informative, all mapped to HLA-G. Typing patients and 
      controls for HLA-G polymorphism revealed significant differences in the exon 8 
      deletion/insertion variant. The latter is probably associated with the efficiency 
      of transcription of this gene. Taken together, the results suggest that HLA-G is 
      associated with PV in Jewish patients.
FAU - Gazit, Ephraim
AU  - Gazit E
AD  - Tissue Typing Laboratory, Sheba Medical Center, Tel-Hashomer, Israel. 
      egazit@post.tau.ac.il
FAU - Slomov, Yelena
AU  - Slomov Y
FAU - Goldberg, Ilan
AU  - Goldberg I
FAU - Brenner, Sarah
AU  - Brenner S
FAU - Loewenthal, Ron
AU  - Loewenthal R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Exons/genetics
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Jews/*genetics
MH  - Microsatellite Repeats
MH  - Mutagenesis, Insertional
MH  - Pemphigus/ethnology/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Sequence Deletion
EDAT- 2004/01/01 05:00
MHDA- 2004/09/10 05:00
CRDT- 2004/01/01 05:00
PHST- 2004/01/01 05:00 [pubmed]
PHST- 2004/09/10 05:00 [medline]
PHST- 2004/01/01 05:00 [entrez]
AID - S0198885903006189 [pii]
AID - 10.1016/j.humimm.2003.09.019 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Jan;65(1):39-46. doi: 10.1016/j.humimm.2003.09.019.