PMID- 14700595
OWN - NLM
STAT- MEDLINE
DCOM- 20040909
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 1
DP  - 2004 Jan
TI  - HLA haplotypes associated with type 1 diabetes mellitus in North Indian children.
PG  - 47-53
AB  - Human leukocyte antigen (HLA) encoded susceptibility to develop type 1 diabetes 
      mellitus (T1DM) has been investigated in children from North India. The results 
      revealed significantly increased prevalence of HLA-A26, -B8, and -B50 among 
      patients and strong positive association of the disease with DRB1*0301 (82.1% vs 
      13.9%, chi2=71.3, odds ratio [OR]=28.3) and a negative association with DRB1*02 
      (chi2=12.2, PF=38.5). HLA-DQB1*0201 occurred in 96.4% of the patients, whereas 
      the heterodimer DQA1*0501-DQB1*0201 was present in 82.1% of patients (60.7% in 
      single dose and 21.4% in double dose) and revealed significant deviation from the 
      healthy controls (chi2=74.1, pc=6.0E-10). In addition to DRB1*03, positive 
      association was also observed with DRB1*09 (14.3% vs 1.3%, chi2=13.4) and DRB1*04 
      (39.3% vs 15.6%, chi2=8.39). No HLA association was observed in relation to 
      residual pancreatic beta-cell function or associated thyroid autoimmunity. Family 
      analysis revealed involvement of multiple DR3+ve haplotypes with T1DM in North 
      Indian children with A26-B8-DRB1*03 (25% vs 3.5%, chi2=16.9, p=3.96E-05) and 
      Ax-B50-DRB1*03 (25% vs 0.7%, chi2=44.7, p=9.88E-11) being the most frequent 
      haplotypes encountered among patients. The classical Caucasian haplotype 
      A1-B8-DRB1*03 was infrequent (7.2%) among the diabetic children. The study 
      highlights the race specificity of HLA association and disease associated HLA 
      haplotypes in T1DM among North Indian children.
FAU - Kanga, Uma
AU  - Kanga U
AD  - Department of Transplant Immunology, All India Institute of Medical Sciences, New 
      Delhi, India.
FAU - Vaidyanathan, Balu
AU  - Vaidyanathan B
FAU - Jaini, Ritika
AU  - Jaini R
FAU - Menon, Puthezath S N
AU  - Menon PS
FAU - Mehra, Narinder K
AU  - Mehra NK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Autoimmune Diseases/ethnology/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/ethnology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*analysis/genetics
MH  - HLA-DQ Antigens/analysis/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/analysis/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/*genetics
MH  - Humans
MH  - India/epidemiology
MH  - Infant
MH  - Male
MH  - Phenotype
MH  - Thyroiditis, Autoimmune/ethnology/genetics
EDAT- 2004/01/01 05:00
MHDA- 2004/09/10 05:00
CRDT- 2004/01/01 05:00
PHST- 2004/01/01 05:00 [pubmed]
PHST- 2004/09/10 05:00 [medline]
PHST- 2004/01/01 05:00 [entrez]
AID - S0198885903006438 [pii]
AID - 10.1016/j.humimm.2003.10.013 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Jan;65(1):47-53. doi: 10.1016/j.humimm.2003.10.013.