PMID- 14700597
OWN - NLM
STAT- MEDLINE
DCOM- 20040909
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 1
DP  - 2004 Jan
TI  - MHC class I and class II genes in Mexican patients with Chagas disease.
PG  - 60-5
AB  - Chagas' disease contributes significantly to cardiovascular morbidity and 
      mortality in several Latin-American countries. Previous studies have reported the 
      effect of the human leukocyte antigen (HLA) molecules in the immune response 
      regulation of Trypanosoma cruzi infection, and the association of HLA antigens 
      with heart damage. We studied the major histocompatibility complex (MHC) class I 
      (HLA-A and HLA-B), and class II (HLA-DR) genes in a sample of 66 serologically 
      positive individuals with and without cardiomyopathy, and in 127 healthy 
      controls. The total group of seropositive individuals revealed increased 
      frequencies of HLA-B39 (pc=4.3x10(-5), odds ratio [OR]=3.35) and DR4 
      (pc=1.8x10(-5), OR=2.91) when compared to healthy controls. Increased frequencies 
      of HLA-A68 and HLA-B39 were found in asymptomatic individuals when compared to 
      patients with cardiomyopathy (pc=0.014, OR=4.99 and pc=0.001, OR=4.46, 
      respectively). Also, patients with cardiomyopathy exhibited increased frequency 
      of HLA-B35 when compared to healthy controls (pc=0.048, OR=2.56). The HLA-DR16 
      frequency was increased in patients with cardiomyopathy compared with 
      asymptomatic individuals (pc=0.05, OR=No determined) and healthy controls 
      (pc=0.02, OR=5.0). The results suggest that MHC alleles might be associated with 
      the development of chronic infection and with heart damage in Chagas' disease. 
      HLA-DR4 and HLA-B39 could be associated directly with the infection by T. cruzi, 
      whereas, HLA-DR16 could be marker of susceptibility to heart damage and HLA-A68 
      might confer protection to develop cardiomyopathy.
FAU - Cruz-Robles, David
AU  - Cruz-Robles D
AD  - Department of Pathology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico 
      DF, Mexico.
FAU - Reyes, Pedro Antonio
AU  - Reyes PA
FAU - Monteon-Padilla, Victor Manuel
AU  - Monteon-Padilla VM
FAU - Ortiz-Muniz, Alda Rocio
AU  - Ortiz-Muniz AR
FAU - Vargas-Alarcon, Gilberto
AU  - Vargas-Alarcon G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Antibodies, Protozoan/blood/immunology
MH  - Chagas Cardiomyopathy/epidemiology/genetics
MH  - Chagas Disease/epidemiology/*genetics
MH  - Ethnicity/genetics
MH  - Gene Frequency
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Immunity, Innate
MH  - Mexico/epidemiology
MH  - Odds Ratio
MH  - Trypanosoma cruzi/immunology
EDAT- 2004/01/01 05:00
MHDA- 2004/09/10 05:00
CRDT- 2004/01/01 05:00
PHST- 2004/01/01 05:00 [pubmed]
PHST- 2004/09/10 05:00 [medline]
PHST- 2004/01/01 05:00 [entrez]
AID - S0198885903006360 [pii]
AID - 10.1016/j.humimm.2003.10.008 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Jan;65(1):60-5. doi: 10.1016/j.humimm.2003.10.008.