PMID- 14701704
OWN - NLM
STAT- MEDLINE
DCOM- 20040617
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 103
IP  - 9
DP  - 2004 May 1
TI  - Interleukin-10 and tumor necrosis factor alpha region haplotypes predict 
      transplant-related mortality after unrelated donor stem cell transplantation.
PG  - 3599-602
AB  - Certain cytokine gene polymorphisms have been shown to correlate with outcome of 
      human leukocyte antigen (HLA) identical sibling donor stem cell transplantation 
      (SCT), but in unrelated donor SCT such information is scarce. We have studied the 
      association between cytokine gene polymorphism and transplant-related mortality 
      (TRM) in 182 unrelated SCTs performed at a single center. We found association of 
      polymorphism in the tumor necrosis factor alpha (TNF alpha) and interleukin-10 
      (IL-10) gene and TRM. Both the TNFd4 allele and the TNF alpha -1031C alleles are 
      associated with high risk for TRM. Statistical analysis showed that both 
      polymorphisms were present on a single haplotype. This haplotype was associated 
      with high risk of TRM when present in recipient or donor, 55% (43%-67%) compared 
      with 21% (12%-30%) when absent from both (P <.01). A further allele associated 
      with this haplotype, TNFa5, is also associated with increased risk of TRM. For 
      IL-10, presence of the donor R2-G-C-C haplotype was associated with decreased 
      risk of TRM, 61% (43%-79%) versus 34% (25%-43%), P =.01. In contrast, possession 
      of the R3-G-C-C haplotype by the donor predicted reduced risk of TRM, 30% 
      (19%-41%, 95% CI) versus 53% (40%-66%, 95% CI), P =.01. No independent 
      associations of cytokine polymorphisms with acute graft-versus-host disease were 
      shown.
FAU - Keen, Leigh J
AU  - Keen LJ
AD  - Molecular Immunogenetics Laboratory, Department of Pathology and Microbiology, 
      University of Bristol, United Kingdom.
FAU - DeFor, Todd E
AU  - DeFor TE
FAU - Bidwell, Jeffrey L
AU  - Bidwell JL
FAU - Davies, Stella M
AU  - Davies SM
FAU - Bradley, Benjamin A
AU  - Bradley BA
FAU - Hows, Jill M
AU  - Hows JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20031230
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Gene Frequency
MH  - Graft vs Host Disease/genetics
MH  - *Haplotypes
MH  - Hematopoietic Stem Cell Transplantation/adverse effects/*mortality
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Polymorphism, Genetic
MH  - Probability
MH  - Prognosis
MH  - Tissue Donors
MH  - Transplantation, Homologous/adverse effects/mortality
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2004/01/01 05:00
MHDA- 2004/06/18 05:00
CRDT- 2004/01/01 05:00
PHST- 2004/01/01 05:00 [pubmed]
PHST- 2004/06/18 05:00 [medline]
PHST- 2004/01/01 05:00 [entrez]
AID - S0006-4971(20)43761-9 [pii]
AID - 10.1182/blood-2002-11-3568 [doi]
PST - ppublish
SO  - Blood. 2004 May 1;103(9):3599-602. doi: 10.1182/blood-2002-11-3568. Epub 2003 Dec 
      30.