PMID- 14702200
OWN - NLM
STAT- MEDLINE
DCOM- 20040830
LR  - 20170417
IS  - 0213-3911 (Print)
IS  - 0213-3911 (Linking)
VI  - 19
IP  - 1
DP  - 2004 Jan
TI  - Dendritic cells: sentinels against pathogens.
PG  - 317-24
LID - 10.14670/HH-19.317 [doi]
AB  - Dendritic cells (DCs) are the most potent antigen-presenting cells, and are 
      regarded as "natural adjuvants" for the induction of primary T or T-dependent 
      immunity. DCs in the peripheral sites capture and process antigens. Encounter of 
      exogenous or endogenous stimuli mature the function of DCs, and they thus acquire 
      T-cell stimulatory capacity and distinct chemotactic behavior which enables them 
      to migrate to lymphoid tissue. In the secondary lymphoid organs, they present 
      antigens to T- and B-cells and stimulate their proliferation. Dendritic cells are 
      also involved in tolerance induction, in particular, to self antigens. DCs also 
      play a key role in the transmission of many pathogens, and therefore may become 
      targets for designing new therapies. DCs have been manipulated in vitro and in 
      vivo for cancer immunotherapy. In this article, we provide a concise overview of 
      DC biology and its current and future role in clinical settings.
FAU - Chung, N P-Y
AU  - Chung NP
AD  - Department of Surgery, The University of Hong Kong Medical Center, Queen Mary 
      Hospital, Pokfulam Road, Hong Kong.
FAU - Chen, Y
AU  - Chen Y
FAU - Chan, Vera S F
AU  - Chan VS
FAU - Tam, P K H
AU  - Tam PK
FAU - Lin, C-L S
AU  - Lin CL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Division
MH  - Cell Movement
MH  - Dendritic Cells/*physiology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunotherapy
MH  - Models, Biological
MH  - Neoplasms/therapy
MH  - T-Lymphocytes/metabolism
RF  - 71
EDAT- 2004/01/01 05:00
MHDA- 2004/08/31 05:00
CRDT- 2004/01/01 05:00
PHST- 2004/01/01 05:00 [pubmed]
PHST- 2004/08/31 05:00 [medline]
PHST- 2004/01/01 05:00 [entrez]
AID - 10.14670/HH-19.317 [doi]
PST - ppublish
SO  - Histol Histopathol. 2004 Jan;19(1):317-24. doi: 10.14670/HH-19.317.