PMID- 14705214
OWN - NLM
STAT- MEDLINE
DCOM- 20040427
LR  - 20220321
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 31
IP  - 1
DP  - 2004 Jan
TI  - Tumor necrosis factor-alpha production is associated with less body cell mass in 
      women with rheumatoid arthritis.
PG  - 23-9
AB  - OBJECTIVE: To examine the relationship between inflammatory cytokine production 
      and body cell mass (BCM) in women with stable, medically well-controlled 
      rheumatoid arthritis (RA). METHODS: Case-control study of 20 women with RA and 20 
      healthy women matched for age, race, and body mass index (kg/m2). Tumor necrosis 
      factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), and IL-6 production were 
      measured by specific, non-cross-reacting ELISA of peripheral blood mononuclear 
      cells (PBMC) cultured with and without 100 ng/ml of endotoxin. Total BCM was 
      assessed by the reference method of whole-body counting of naturally occurring 
      radioactive potassium-40. RESULTS: Patients with RA were cachectic, with 14% less 
      BCM (p < 0.001) and higher TNF-alpha production (p < 0.05) than controls. 
      TNF-alpha production was inversely associated with BCM both without (r = -0.51, p 
      = 0.03) and with (r = -0.57, p = 0.01) endotoxin stimulation in patients but not 
      in controls. In multivariate linear regression models, these inverse associations 
      remained significant after adjustment for age and physical activity. No 
      association was found for IL-1beta or IL-6 production in these models. 
      CONCLUSION: Women with stable, medically well-controlled RA have lower than 
      normal BCM that is inversely associated with elevated TNF-alpha production.
FAU - Walsmith, Joseph
AU  - Walsmith J
AD  - Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 
      Boston, Massachusetts 02111, USA.
FAU - Abad, Leslie
AU  - Abad L
FAU - Kehayias, Joseph
AU  - Kehayias J
FAU - Roubenoff, Ronenn
AU  - Roubenoff R
LA  - eng
GR  - M01 RR00054/RR/NCRR NIH HHS/United States
GR  - P30-DK-46200/DK/NIDDK NIH HHS/United States
GR  - T32 AG00209-09/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/*immunology/*metabolism
MH  - Body Composition
MH  - *Body Mass Index
MH  - Cachexia/immunology/metabolism
MH  - Case-Control Studies
MH  - Cytokines/metabolism
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2004/01/06 05:00
MHDA- 2004/04/28 05:00
CRDT- 2004/01/06 05:00
PHST- 2004/01/06 05:00 [pubmed]
PHST- 2004/04/28 05:00 [medline]
PHST- 2004/01/06 05:00 [entrez]
AID - 0315162X-31-23 [pii]
PST - ppublish
SO  - J Rheumatol. 2004 Jan;31(1):23-9.