PMID- 14705987
OWN - NLM
STAT- MEDLINE
DCOM- 20040826
LR  - 20190827
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 63
IP  - 2
DP  - 2004 Feb
TI  - Human leukocyte antigen-A, -B, and -Cw polymorphism in a Berber population from 
      North Morocco using sequence-based typing.
PG  - 158-72
AB  - Class I human leukocyte antigen (HLA) polymorphism was examined in a Berber 
      population from North Morocco, named Metalsa (ME). All data were obtained at 
      high-resolution level, using sequence-based typing. The most frequent alleles 
      were: HLA-A*0201 and A*0101; HLA-B*44 (B*4403 and B*4402); B*0801 and the B*50 
      allele group (B*5001 and B*5002); HLA-Cw*0602; and Cw*07 group (Cw*070101, 
      Cw*070102, Cw*0702, Cw*0704, and Cw*0706), and Cw*040101. The novel HLA-B*570302 
      allele was identified. It differs at position 486 and position 855 from B*570301, 
      resulting in synonymous Thr and Val. The analysis also evidenced some alleles 
      common in Africans (A*3402, A*6802, A*7401, B*1503, B*4102, B*4202, B*7801, 
      B*5802, Cw*1701, and Cw*1703) and some uncommon alleles (A*3004, B*2702, B*2703, 
      B*5001,02, B*3503, and Cw*0706). The predominant HLA-A-Cw-B-DRB1-extended 
      haplotypes in ME population were A*0101-Cw*0501-B*4402-DRB1*0402, 
      A*240201-Cw*0701-B*0801-DRB1*030101, A*2301-Cw*040101-B*4403-DRB1*040501, 
      A*0201-Cw*040101-B*4403-DRB1*1302, and A*3002-Cw*0602-B*5002-DRB1*0406. This 
      study demonstrates a strong relatedness of ME to other Moroccan and North African 
      populations, some characteristics of sub-Saharan Africans and evidenced the 
      influence of various immigrations during centuries. Nevertheless, this study 
      highlights some unique genetic traits of the ME population compared to other 
      ethnic groups within Morocco, which could be of great interest for clinical aims, 
      transplantation, and diseases.
FAU - Piancatelli, D
AU  - Piancatelli D
AD  - C.N.R. Istituto per i Trapianti d'Organo e l'Immunocitologia, L'Aquila, Italy.
FAU - Canossi, A
AU  - Canossi A
FAU - Aureli, A
AU  - Aureli A
FAU - Oumhani, K
AU  - Oumhani K
FAU - Del Beato, T
AU  - Del Beato T
FAU - Di Rocco, M
AU  - Di Rocco M
FAU - Liberatore, G
AU  - Liberatore G
FAU - Tessitore, A
AU  - Tessitore A
FAU - Witter, K
AU  - Witter K
FAU - El Aouad, R
AU  - El Aouad R
FAU - Adorno, D
AU  - Adorno D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*04:06 antigen)
RN  - 0 (HLA-C*17:01 antigen)
SB  - IM
MH  - Adult
MH  - Africa
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genetic Linkage
MH  - Genetics, Population
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Morocco
MH  - Phylogeny
MH  - *Polymorphism, Genetic
MH  - Sequence Analysis, DNA
RF  - 71
EDAT- 2004/01/07 05:00
MHDA- 2004/08/27 05:00
CRDT- 2004/01/07 05:00
PHST- 2004/01/07 05:00 [pubmed]
PHST- 2004/08/27 05:00 [medline]
PHST- 2004/01/07 05:00 [entrez]
AID - 161 [pii]
AID - 10.1111/j.1399-0039.2004.00161.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Feb;63(2):158-72. doi: 10.1111/j.1399-0039.2004.00161.x.