PMID- 14707415
OWN - NLM
STAT- MEDLINE
DCOM- 20040709
LR  - 20131121
IS  - 1015-9770 (Print)
IS  - 1015-9770 (Linking)
VI  - 17
IP  - 2-3
DP  - 2004
TI  - Hyperhomocysteinemia and other newly recognized inherited coagulation disorders 
      (factor V Leiden and prothrombin gene mutation) in patients with idiopathic 
      cerebral vein thrombosis.
PG  - 153-9
AB  - BACKGROUND: Idiopathic cerebral vein thrombosis (iCVT) represents approximately 
      30% of the cases of cerebral vein thrombosis (CVT). New, inherited - factor V 
      Leiden (FVL) and prothrombin gene mutation (PTHRA20210) - and inherited/acquired 
      - hyperhomocysteinemia (HHcy) - prothrombotic conditions have been detected 
      recently. METHODS: We assessed fasting plasma homocysteine (Hcy) levels and main 
      Hcy determinants, FVL and PTHRA(20210) in 30 patients with documented iCVT and 40 
      age- and sex-matched healthy subjects. RESULTS: A strong and significant 
      association of PTHRA(20210) [30% (9/30) vs. 2.5% (1/40) iCVT vs. controls, 
      respectively, p = 0.001; OR = 16.174, p = 0.002] and HHcy [13/30 (43.3%) vs. 4/40 
      (10%) iCVT vs. controls, respectively; p = 0.002, OR = 6.88, p = 0.002] with iCVT 
      was found. CONCLUSIONS: PTHRA(20210) and HHcy should be considered when screening 
      for thrombophilia and should be assessed in patients with a family or personal 
      history of CVT.
CI  - Copyright 2004 S. Karger AG, Basel
FAU - Ventura, Paolo
AU  - Ventura P
AD  - Department of Internal Medicine, University of Modena and Reggio Emilia, Italy. 
      paoloven@unimore.it
FAU - Cobelli, Milena
AU  - Cobelli M
FAU - Marietta, Marco
AU  - Marietta M
FAU - Panini, Rossana
AU  - Panini R
FAU - Rosa, Maria Cristina
AU  - Rosa MC
FAU - Salvioli, Gianfranco
AU  - Salvioli G
LA  - eng
PT  - Journal Article
DEP - 20031223
PL  - Switzerland
TA  - Cerebrovasc Dis
JT  - Cerebrovascular diseases (Basel, Switzerland)
JID - 9100851
RN  - 0 (Protein C)
RN  - 0 (Protein S)
RN  - 0 (factor V Leiden)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 9000-94-6 (Antithrombin III)
RN  - 9001-24-5 (Factor V)
RN  - 9001-26-7 (Prothrombin)
SB  - IM
MH  - Adult
MH  - Antithrombin III/metabolism
MH  - Cerebral Veins
MH  - Factor V/*genetics
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/*epidemiology/*genetics
MH  - Intracranial Thrombosis/*epidemiology/*genetics
MH  - Male
MH  - Point Mutation
MH  - Prevalence
MH  - Protein C/metabolism
MH  - Protein S/metabolism
MH  - Prothrombin/*genetics
MH  - Risk Factors
MH  - Thrombophilia/epidemiology/genetics
MH  - Venous Thrombosis/epidemiology/genetics
EDAT- 2004/01/07 05:00
MHDA- 2004/07/10 05:00
CRDT- 2004/01/07 05:00
PHST- 2003/04/02 00:00 [received]
PHST- 2003/07/08 00:00 [accepted]
PHST- 2004/01/07 05:00 [pubmed]
PHST- 2004/07/10 05:00 [medline]
PHST- 2004/01/07 05:00 [entrez]
AID - 75784 [pii]
AID - 10.1159/000075784 [doi]
PST - ppublish
SO  - Cerebrovasc Dis. 2004;17(2-3):153-9. doi: 10.1159/000075784. Epub 2003 Dec 23.