PMID- 14708051
OWN - NLM
STAT- MEDLINE
DCOM- 20040826
LR  - 20230320
IS  - 0364-2313 (Print)
IS  - 0364-2313 (Linking)
VI  - 28
IP  - 2
DP  - 2004 Feb
TI  - Serum monocyte chemoattractant protein-1 in patients with postoperative 
      infectious complications from gastrointestinal surgery for cancer.
PG  - 130-6
AB  - We examined the kinetics of serum monocyte chemoattractant protein-1 (MCP-1) 
      perioperatively and clarified its significance regarding the development of 
      infectious complications. We studied 94 patients who underwent gastrointestinal 
      surgery for gastric or colorectal cancer at Mie University Hospital from 1996 to 
      2000. Serum concentrations of MCP-1 and interleukin-6 (IL-6) were measured 
      perioperatively. The number of circulating lymphocytes and neutrophils were 
      counted to assess the apoptotic rate of neutrophils. Patients were divided into 
      two groups at the median preoperative MCP-1 level obtained from 40 gender- and 
      age-matched healthy volunteers. The rate of developing infectious complications 
      was significantly higher and tumor size was significantly larger in the low MCP-1 
      group than in the high MCP-1 group. The increasing IL-6 ratio 
      (postoperative/preoperative IL-6 level) in the low MCP-1 group was about twofold 
      greater than that in the high MCP-1 group. The neutrophil level calculated for 
      the low MCP-1 group was significantly higher than that in the high MCP-1 group on 
      postoperative day 3. We concluded that a decreased level of serum MCP-1 reflected 
      tumor-related immunosuppression. Low MCP-1 levels were associated with an 
      exaggerated postoperative IL-6 response and delayed neutrophil apoptosis, which 
      affected the incidence of postoperative infectious complications developing in 
      patients with gastrointestinal malignancies.
FAU - Tonouchi, Hitoshi
AU  - Tonouchi H
AD  - Department of Innovative Surgery, Mie University School of Medicine, Edobashi 
      2-174, Tsu-City, 514-8507 Mie, Japan.
FAU - Miki, Chikao
AU  - Miki C
FAU - Ohmori, Yukinari
AU  - Ohmori Y
FAU - Kobayashi, Minako
AU  - Kobayashi M
FAU - Mohri, Yasuhiko
AU  - Mohri Y
FAU - Tanaka, Kouji
AU  - Tanaka K
FAU - Konishi, Naomi
AU  - Konishi N
FAU - Kusunoki, Masato
AU  - Kusunoki M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040108
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apoptosis/physiology
MH  - Chemokine CCL2/*blood
MH  - Colorectal Neoplasms/*surgery
MH  - Female
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Interleukin-6/blood
MH  - Leukocyte Count
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Neutrophils/immunology
MH  - Reference Values
MH  - Risk Factors
MH  - Stomach Neoplasms/immunology/*surgery
MH  - Surgical Wound Infection/diagnosis/*immunology
EDAT- 2004/01/07 05:00
MHDA- 2004/08/27 05:00
CRDT- 2004/01/07 05:00
PHST- 2004/01/07 05:00 [pubmed]
PHST- 2004/08/27 05:00 [medline]
PHST- 2004/01/07 05:00 [entrez]
AID - 10.1007/s00268-003-7152-z [doi]
PST - ppublish
SO  - World J Surg. 2004 Feb;28(2):130-6. doi: 10.1007/s00268-003-7152-z. Epub 2004 Jan 
      8.