PMID- 14708713
OWN - NLM
STAT- MEDLINE
DCOM- 20040602
LR  - 20191108
IS  - 1044-579X (Print)
IS  - 1044-579X (Linking)
VI  - 13
IP  - 5
DP  - 2003 Oct
TI  - HLA-G and IL-10 expression in human cancer--different stories with the same 
      message.
PG  - 337-42
AB  - Immune evasion in cancer may result from structural and functional alterations of 
      human leukocyte antigen (HLA) class I molecules and/or local release of 
      immunosuppressive cytokines, such as interleukin (IL)-10. In lung cancer, both of 
      these mechanisms seem to often take place, resulting in the impaired tumor 
      recognition and the progression of the disease. In primary cutaneous lymphomas on 
      the other side, the shift towards immunosuppressive T helper (Th)2 cytokine 
      profile and the secretion of IL-10 appears to occur more frequently than the loss 
      of HLA class I molecules. In addition to down-regulation of HLA class I 
      expression, IL-IO appears to be one of the factors responsible for the 
      up-regulation of HLA-G, another molecule involved in the immunescape. It is 
      possible that the expression of HLA-G itself may account for induction of 
      Th2-skewing state and the production of IL-10, thence establishing a vicious 
      circle of immune abrogation in cancer. This article reviews the current 
      literature on this topic and provides new insights into the role of HLA-G and 
      IL-10 in cancer.
FAU - Urosevic, Mirjana
AU  - Urosevic M
AD  - Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, Zurich 
      8091, Switzerland. Mirjana.Urosevic@usz.ch
FAU - Dummer, Reinhard
AU  - Dummer R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Semin Cancer Biol
JT  - Seminars in cancer biology
JID - 9010218
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Disease Progression
MH  - HLA Antigens/*biosynthesis
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*biosynthesis
MH  - Humans
MH  - Interleukin-10/*biosynthesis
MH  - Models, Biological
MH  - Neoplasms/*immunology/*metabolism
MH  - Phenotype
MH  - Skin Neoplasms/immunology/metabolism
RF  - 61
EDAT- 2004/01/08 05:00
MHDA- 2004/06/03 05:00
CRDT- 2004/01/08 05:00
PHST- 2004/01/08 05:00 [pubmed]
PHST- 2004/06/03 05:00 [medline]
PHST- 2004/01/08 05:00 [entrez]
AID - 10.1016/s1044-579x(03)00024-5 [doi]
PST - ppublish
SO  - Semin Cancer Biol. 2003 Oct;13(5):337-42. doi: 10.1016/s1044-579x(03)00024-5.