PMID- 14709856
OWN - NLM
STAT- MEDLINE
DCOM- 20040930
LR  - 20190906
IS  - 0918-8959 (Print)
IS  - 0918-8959 (Linking)
VI  - 50
IP  - 6
DP  - 2003 Dec
TI  - The prevalence of late onset congenital adrenal hyperplasia in hirsute women from 
      Central Anatolia.
PG  - 815-23
AB  - Late onset congenital adrenal hyperplasia (LO CAH) can be seen in association 
      with polycystic ovary syndrome (PCOS) or idiopathic hirsutism (IH). The study 
      aimed to find out the prevalence of LO CAH in Central Anatolia among hirsute 
      women. Sixty-three patients with hirsutism were evaluated to determine the 
      frequency of LO CAH by comparing them with their age and body mass index matched 
      28 healthy controls. Of those 63 hirsute women, 43 were diagnosed as PCOS, and 20 
      were diagnosed as IH. Following basal hormonal evaluation, all subjects underwent 
      ACTH stimulation test and ACTH stimulated 17-hydroxyprogesterone (17-OH P), 
      11-desoxycortisol (11-DOC), cortisol (F), and dehydroepiandrosterone sulfate 
      (DHEA-S) levels were determined in all subjects. ACTH stimulated 17-OH P, 11-DOC, 
      and DHEA-S levels did not differ between groups. However, stimulated F levels 
      were found to be higher in hirsute women (p<0.001). Six out of 63 (9.52%) 
      patients with hirsutism met the criterion for 21 hydroxylase deficiency. We found 
      no subject presumed to have 11-beta hydroxylase deficiency, but one subject in 
      control group (3.57%) and two patients among PCOS subjects (4.65%) had 
      exaggerated DHEA-S response which was suggestive of mild 3-beta hydroxysteroid 
      dehydrogenase deficiency. In conclusion, the most frequent form of LO CAH seems 
      to be due to 21 OH deficiency among women with PCOS and IH in Central Anatolia. 
      Mild 3-beta HSD deficiency may also be an underlying cause for hirsutism and it 
      may be seen without any clinical presentation. Adrenal hyperactivity is likely to 
      be the main reason of hyperandrogenemia in women with hirsutism.
FAU - Kamel, Nuri
AU  - Kamel N
AD  - Department of Endocrinology and Metabolic Diseases, Ankara University, School of 
      Medicine, Ankara, Turkey.
FAU - Tonyukuk, Vedia
AU  - Tonyukuk V
FAU - Emral, Rifat
AU  - Emral R
FAU - Corapcioglu, Demet
AU  - Corapcioglu D
FAU - Bastemir, Mehmet
AU  - Bastemir M
FAU - Gullu, Sevim
AU  - Gullu S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
RN  - 68-96-2 (17-alpha-Hydroxyprogesterone)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - EC 1.14.14.16 (Steroid 21-Hydroxylase)
RN  - WDT5SLP0HQ (Cortodoxone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - 17-alpha-Hydroxyprogesterone/blood
MH  - Adrenal Hyperplasia, Congenital/blood/*complications/diagnosis/*epidemiology
MH  - Adrenocorticotropic Hormone
MH  - Age Distribution
MH  - Age of Onset
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cortodoxone/blood
MH  - Dehydroepiandrosterone Sulfate/blood
MH  - Female
MH  - Hirsutism/blood/*complications
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Polycystic Ovary Syndrome/complications
MH  - Prevalence
MH  - Steroid 21-Hydroxylase/blood
MH  - Turkey/epidemiology
EDAT- 2004/01/08 05:00
MHDA- 2004/10/01 05:00
CRDT- 2004/01/08 05:00
PHST- 2004/01/08 05:00 [pubmed]
PHST- 2004/10/01 05:00 [medline]
PHST- 2004/01/08 05:00 [entrez]
AID - 10.1507/endocrj.50.815 [doi]
PST - ppublish
SO  - Endocr J. 2003 Dec;50(6):815-23. doi: 10.1507/endocrj.50.815.