PMID- 14710230
OWN - NLM
STAT- MEDLINE
DCOM- 20040224
LR  - 20220309
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 90
IP  - 1
DP  - 2004 Jan 12
TI  - Impact of frequent Bcl-2 expression on better prognosis in renal cell carcinoma 
      patients.
PG  - 200-5
AB  - Previously, we reported that Bcl-2 was frequently expressed in renal cell 
      carcinoma (RCC) specimens, but p53 mutation was a rare event. However, it was 
      unclear whether Bcl-2 positivity was associated with the clinicopathological 
      characteristics and prognosis in RCC. Therefore, we investigated the expression 
      of Bcl-2 protein and its roles in 101 RCC specimens. In addition, the 
      proliferation index (PI), apoptotic index (AI), caspase-3 and p53 expression were 
      examined. The immunohistochemical method was applied for Bcl-2, caspase-3 and p53 
      protein expression. To investigate the proliferation activity and apoptosis of 
      tumour cells, PI and AI were calculated based on Ki-67 and terminal 
      deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labelling 
      (TUNEL)-positive cells, respectively. Bcl-2 expression was detected in 72 out of 
      101 (71.3%) specimens. Bcl-2 positivity was inversely correlated with PI 
      (P<0.0001) and AI (P=0.0074). Furthermore, Bcl-2 positivity was significantly 
      correlated with better survival (P=0.0014), and was associated with lower stage 
      (P=0.0301) and grade (P=0.0020). In RCC, frequent Bcl-2 expression was correlated 
      with favourable character without higher PI and AI. Thus, Bcl-2 expression might 
      be applied as a novel predictor of better prognosis in RCC patients.
FAU - Itoi, T
AU  - Itoi T
AD  - Division of Molecular Oncology, Department of Signal Transduction Research, 
      Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 
      1-757, Niigata 951-8510, Japan.
FAU - Yamana, K
AU  - Yamana K
FAU - Bilim, V
AU  - Bilim V
FAU - Takahashi, K
AU  - Takahashi K
FAU - Tomita, F
AU  - Tomita F
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apoptosis
MH  - Carcinoma, Renal Cell/*genetics/*pathology
MH  - Cell Division
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - *Genes, bcl-2
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney Neoplasms/*genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-bcl-2/*biosynthesis
MH  - Survival Analysis
PMC - PMC2395310
EDAT- 2004/01/08 05:00
MHDA- 2004/02/26 05:00
PMCR- 2005/01/06
CRDT- 2004/01/08 05:00
PHST- 2004/01/08 05:00 [pubmed]
PHST- 2004/02/26 05:00 [medline]
PHST- 2004/01/08 05:00 [entrez]
PHST- 2005/01/06 00:00 [pmc-release]
AID - 6601454 [pii]
AID - 10.1038/sj.bjc.6601454 [doi]
PST - ppublish
SO  - Br J Cancer. 2004 Jan 12;90(1):200-5. doi: 10.1038/sj.bjc.6601454.