PMID- 14711457
OWN - NLM
STAT- MEDLINE
DCOM- 20040819
LR  - 20191108
IS  - 0955-2863 (Print)
IS  - 0955-2863 (Linking)
VI  - 15
IP  - 1
DP  - 2004 Jan
TI  - Decreased serum leptin and muscle oxidative enzyme activity with a dietary loss 
      of intra-abdominal fat in rats.
PG  - 24-9
AB  - The purpose of the present study was to investigate the relationship among 
      intra-abdominal adipose storage, adaptation in the serum leptin concentration and 
      skeletal muscle enzyme activity after a 4-week energy restriction (ER). 
      Thirty-one male Wistar rats were divided into 40% energy restricted (n=24) or ad 
      libitum-fed control (CL) rats (n=7). The energy-restricted rats were grouped into 
      the most fat (MF, n=7), medium (n 10) and the least fat (LF, n=7) by their 
      intra-abdominal fat pads mass (epididymal, mesenteric, and perirenal) after ER. A 
      superficial portion of M. gastrocnemius tissue obtained before and after the diet 
      period were analyzed to determine the activities of hexokinase (HK), 
      beta-hydroxyacyl CoA dehydrogenase (beta-HAD) and citrate synthase (CS). Blood 
      samples were also collected for a serum leptin assay. At the baseline, no 
      difference was found in either the leptin concentration or the enzyme activities 
      among LF, MF and CL. The serum leptin concentration was positively correlated 
      with the muscle activities of beta-HAD and CS, while it negatively correlated 
      with HK/beta-HAD. After ER, the activities of HK, beta-HAD and CS were all 
      significantly lower in LF than in CL. Among the energy-restricted rats, the 
      intra-abdominal fat pad weight, leptin concentration and the activities of 
      beta-HAD, CS, beta-HAD/CS all significantly correlated with one another. The 
      changes in leptin and the activity of beta-HAD were also positively correlated. 
      These findings indicate that parallel decreases in the serum leptin and skeletal 
      muscle enzyme activities with the energy restriction-induced intra-abdominal 
      adipose reduction, thus may suggest the leptin to have a regulative effect on the 
      muscle enzyme activity during ER.
FAU - Zou, Buhao
AU  - Zou B
AD  - Graduate School of Human-Environment Studies, Kyushu University, Kasuga, Fukuoka 
      816-8580, Japan.
FAU - Suwa, Masataka
AU  - Suwa M
FAU - Nakano, Hiroshi
AU  - Nakano H
FAU - Higaki, Yasuki
AU  - Higaki Y
FAU - Ito, Tatsumi
AU  - Ito T
FAU - Katsuta, Shigeru
AU  - Katsuta S
FAU - Kumagai, Shuzo
AU  - Kumagai S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Leptin)
RN  - EC 1.1.1.- (3-Hydroxyacyl CoA Dehydrogenases)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - 3-Hydroxyacyl CoA Dehydrogenases/metabolism
MH  - Abdomen
MH  - Adipose Tissue/*anatomy & histology
MH  - Animals
MH  - Citrate (si)-Synthase/metabolism
MH  - *Diet, Reducing
MH  - Epididymis
MH  - Hexokinase/metabolism
MH  - Leptin/*blood
MH  - Male
MH  - Muscle, Skeletal/*enzymology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2004/01/09 05:00
MHDA- 2004/08/20 05:00
CRDT- 2004/01/09 05:00
PHST- 2004/01/09 05:00 [pubmed]
PHST- 2004/08/20 05:00 [medline]
PHST- 2004/01/09 05:00 [entrez]
AID - S0955286303001542 [pii]
AID - 10.1016/j.jnutbio.2003.09.004 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2004 Jan;15(1):24-9. doi: 10.1016/j.jnutbio.2003.09.004.