PMID- 14711569
OWN - NLM
STAT- MEDLINE
DCOM- 20040401
LR  - 20201208
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 81
IP  - 1
DP  - 2004 Jan
TI  - Meiosis I arrest and azoospermia in an infertile male explained by failure of 
      formation of a component of the synaptonemal complex.
PG  - 205-9
AB  - OBJECTIVE: To characterize the early stages of meiosis in a male with unexplained 
      azoospermia. DESIGN: Case report. SETTING: Case Western Reserve University and 
      University Hospitals of Cleveland. PATIENT(S): A 30-year-old male with 
      nonobstructive azoospermia. INTERVENTION(S): Immunostaining for components of the 
      synaptonemal complex and recombination-associated proteins, fluorescence in situ 
      hybridization (FISH) for specific chromosomes. MAIN OUTCOME MEASURE(S): 
      Progression to and through pachytene of meiosis I in controls and in the patient. 
      RESULT(S): We observed complete meiosis I arrest in the patient, associated with 
      failure of formation of the mature, tripartite synaptonemal complex. 
      CONCLUSION(S): Abnormalities in synaptonemal complex formation are responsible 
      for a proportion of cases of unexplained male infertility.
FAU - Judis, LuAnn
AU  - Judis L
AD  - Department of Genetics and The Center for Human Genetics, Case Western Reserve 
      University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.
FAU - Chan, Ernest R
AU  - Chan ER
FAU - Schwartz, Stuart
AU  - Schwartz S
FAU - Seftel, Allen
AU  - Seftel A
FAU - Hassold, Terry
AU  - Hassold T
LA  - eng
GR  - R01 HD21341/HD/NICHD NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (SYCP3 protein, human)
RN  - EC 3.1.3.16 (CTDSP1 protein, human)
RN  - EC 3.1.3.16 (Phosphoprotein Phosphatases)
SB  - IM
MH  - Adult
MH  - Cell Cycle Proteins
MH  - DNA-Binding Proteins
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/etiology
MH  - Male
MH  - *Meiosis
MH  - Nuclear Proteins/analysis/metabolism
MH  - Oligospermia/*etiology
MH  - Phosphoprotein Phosphatases/analysis/metabolism
MH  - Spermatocytes/physiology
MH  - Synaptonemal Complex/*metabolism
EDAT- 2004/01/09 05:00
MHDA- 2004/04/02 05:00
CRDT- 2004/01/09 05:00
PHST- 2004/01/09 05:00 [pubmed]
PHST- 2004/04/02 05:00 [medline]
PHST- 2004/01/09 05:00 [entrez]
AID - S0015028203022829 [pii]
AID - 10.1016/j.fertnstert.2003.05.021 [doi]
PST - ppublish
SO  - Fertil Steril. 2004 Jan;81(1):205-9. doi: 10.1016/j.fertnstert.2003.05.021.