PMID- 14712854
OWN - NLM
STAT- MEDLINE
DCOM- 20040326
LR  - 20190911
IS  - 0355-3140 (Print)
IS  - 0355-3140 (Linking)
VI  - 29
IP  - 6
DP  - 2003 Dec
TI  - Nasal symptoms among residents in moldy housing.
PG  - 461-7
AB  - OBJECTIVES: The aim of this study was to determine whether mold allergy mediated 
      through immunoglobulin E (IgE) was responsible for the chronic nasal symptoms 
      experienced by residents of moldy dwellings. A secondary aim was to investigate 
      whether nasal mucosal findings were a possible reflection of other pathological 
      mechanisms of chronic rhinitis. METHODS: Sixteen adults living in moldy housing 
      and complaining of chronic rhinitis were compared with sixteen healthy referents 
      without any known mold exposure. All the buildings were surveyed for visible 
      signs of moisture and mold. Microbial measurements were performed in the damp 
      buildings with mold problems and in half of the reference buildings. The clinical 
      study consisted of an otorhinolaryngological examination, nasal cytology, and 
      skin prick tests. In the study cases, nasal provocation tests with fungi cultured 
      from the homes and nasal mucosal biopsy were performed. RESULTS: In the housing 
      with signs of moisture and mold, the concentrations of microorganisms were 
      elevated, but were within the normal range of those of the reference buildings. 
      The only positive skin reaction for molds was detected in one referent. No 
      reactions were elicited in the nasal provocation tests with molds. Squamous 
      metaplasia were detected in four biopsies and three cytograms of the cases but 
      not in the nasal smears of the referents. CONCLUSIONS: In this material, the 
      respiratory symptoms reported by occupants of moldy residences were not caused by 
      mold allergy but were apparently related to nonspecific inflammation following 
      irritation.
FAU - Ruoppi, Pirkko I
AU  - Ruoppi PI
AD  - Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland. 
      pirkko.ruoppi@kuh.fi
FAU - Husman, Tuula M
AU  - Husman TM
FAU - Reiman, Marjut H
AU  - Reiman MH
FAU - Nuutinen, Juhani
AU  - Nuutinen J
FAU - Hyvarinen, Anne M
AU  - Hyvarinen AM
FAU - Nevalainen, Aino I
AU  - Nevalainen AI
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Finland
TA  - Scand J Work Environ Health
JT  - Scandinavian journal of work, environment & health
JID - 7511540
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Air Pollution, Indoor/*adverse effects
MH  - Case-Control Studies
MH  - Environmental Exposure/adverse effects
MH  - Environmental Monitoring
MH  - Fungi/immunology/*isolation & purification/pathogenicity
MH  - *Housing
MH  - Humans
MH  - Humidity/*adverse effects
MH  - Immunoglobulin E/analysis/immunology
MH  - Middle Aged
MH  - Nasal Provocation Tests
MH  - Respiratory Hypersensitivity/diagnosis/*etiology/immunology
EDAT- 2004/01/10 05:00
MHDA- 2004/03/27 05:00
CRDT- 2004/01/10 05:00
PHST- 2004/01/10 05:00 [pubmed]
PHST- 2004/03/27 05:00 [medline]
PHST- 2004/01/10 05:00 [entrez]
AID - 754 [pii]
AID - 10.5271/sjweh.754 [doi]
PST - ppublish
SO  - Scand J Work Environ Health. 2003 Dec;29(6):461-7. doi: 10.5271/sjweh.754.