PMID- 14713116
OWN - NLM
STAT- MEDLINE
DCOM- 20040209
LR  - 20190622
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 543
DP  - 2003
TI  - Hypoxia and high altitude. The molecular response.
PG  - 89-115
AB  - Increased erythropoietin plasma levels and the consequent augmented production of 
      red blood cells is the best known systemic adaptation to reduced oxygen partial 
      pressure (pO2). Intensive research during the last years revealed that the 
      molecular mechanism behind the regulation of erythropoietin is ubiquitous and has 
      far more implications than first thought. Erythropoietin regulation results from 
      the activation of the hypoxia-inducible factor-1 (HIF-1) pathway under hypoxic 
      conditions. HIF-1 is a heterodimer consisting of an oxygen sensitive--HIF-1--and 
      an oxygen-independent subunit--HIF-1beta (also known as the aryl hydrocarbon 
      receptor nuclear translocator--ARNT). In addition to erythropoietin, more than 30 
      genes are now known to be up-regulated by HIF-1. Recently, the critical 
      involvement of HIF-1alpha post-translational modifications in the cellular oxygen 
      sensing mechanism was discovered. In this review we will focus on the regulation 
      of the HIF-1 pathway and the cellular oxygen sensor and discuss their 
      implications in high altitude hypoxia.
FAU - Hopfl, Gisele
AU  - Hopfl G
AD  - Institute of Veterinary Physiology, University of Zurich, Switzerland.
FAU - Ogunshola, Omolara
AU  - Ogunshola O
FAU - Gassmann, Max
AU  - Gassmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (ARNT protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Transcription Factors)
RN  - 11096-26-7 (Erythropoietin)
RN  - 138391-32-9 (Aryl Hydrocarbon Receptor Nuclear Translocator)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adaptation, Physiological
MH  - Altitude
MH  - Altitude Sickness/blood/genetics/*metabolism
MH  - Animals
MH  - Aryl Hydrocarbon Receptor Nuclear Translocator
MH  - DNA-Binding Proteins/chemistry/genetics/*metabolism
MH  - Erythropoietin/biosynthesis
MH  - Hematocrit
MH  - Humans
MH  - Hypoxia/blood/genetics/*metabolism
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Models, Biological
MH  - Nuclear Proteins/chemistry/genetics/*metabolism
MH  - Oxygen/metabolism
MH  - Phosphorylation
MH  - *Receptors, Aryl Hydrocarbon
MH  - Transcription Factors/chemistry/genetics/metabolism
RF  - 167
EDAT- 2004/01/10 05:00
MHDA- 2004/02/11 05:00
CRDT- 2004/01/10 05:00
PHST- 2004/01/10 05:00 [pubmed]
PHST- 2004/02/11 05:00 [medline]
PHST- 2004/01/10 05:00 [entrez]
AID - 10.1007/978-1-4419-8997-0_7 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2003;543:89-115. doi: 10.1007/978-1-4419-8997-0_7.