PMID- 14714361
OWN - NLM
STAT- MEDLINE
DCOM- 20040224
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 23
IP  - 12
DP  - 2003 Dec
TI  - [Clinical observation on effect of fuzheng yiliu granule on cell cycle and 
      nuclear transcription factor-kappa B in tissue of esophageal-gastric carcinoma].
PG  - 908-10
AB  - OBJECTIVE: To observe the effect of Fuzheng Yiliu Granule (FZYLG) on cell cycle 
      and nuclear transcription factor-kappa B (NF-kappa B) in tissue of 
      esophageal-gastric carcinoma. METHODS: Seventy-six patients with esophageal 
      gastric carcinoma were randomly divided into two groups, the FZYLG group and the 
      control group. FZYLG was given to the former for 15 days. The tumor tissue in 
      both groups was resected and cell cycle and apoptosis rate as well as NF-kappa B 
      were determined by flowcytometry. RESULTS: Level of NF-kappa B in the treated 
      group was significantly higher than that in the control group (P < 0.05). In the 
      treated group, the percentage of G0/G1 stage cells were significantly increased 
      and that of S stage significantly decreased (both P < 0.05). At the same time, 
      obvious cell apoptosis was found in the treated group, the apoptosis rate of 
      which was significantly higher than that in the control group (P < 0.01). 
      CONCLUSION: FZYLG can increase the NF-kappa B expression, block the proliferation 
      to promote the apoptosis of tumor cells.
FAU - Zhao, Jian-xiong
AU  - Zhao JX
AD  - Institute of Integrative Chinese and Western Medicine, Lanzhou Medical College, 
      Lanzhou 730000. Zhaojianxiong@mail.Lazmc.edu.cn
FAU - Qu, Yong
AU  - Qu Y
FAU - Chen, Xue-zhong
AU  - Chen XZ
LA  - chi
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (NF-kappa B)
SB  - IM
MH  - Adenocarcinoma/drug therapy/pathology
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/drug therapy/pathology
MH  - Cell Cycle/drug effects
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Esophageal Neoplasms/*drug therapy/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - NF-kappa B/*metabolism
MH  - *Phytotherapy
MH  - Stomach Neoplasms/*drug therapy/pathology
EDAT- 2004/01/13 05:00
MHDA- 2004/02/26 05:00
CRDT- 2004/01/13 05:00
PHST- 2004/01/13 05:00 [pubmed]
PHST- 2004/02/26 05:00 [medline]
PHST- 2004/01/13 05:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Dec;23(12):908-10.